| Literature DB >> 12744856 |
E Rollman1, T Ramqvist, B Zuber, K Tegerstedt, A Kjerrström Zuber, J Klingström, L Eriksson, K Ljungberg, J Hinkula, B Wahren, T Dalianis.
Abstract
To improve immune responses induced by DNA immunization, murine polyomavirus major capsid protein (VP1) pseudocapsids were complexed with a DNA plasmid encoding the p37 (p24 and p17) nucleocapsid proteins of the human immunodeficiency virus type 1 (HIV-1). A 10-fold increase in antibody titer was noted in mice given DNA plasmid together with VP1 pseudocapsids in comparison to animals that received DNA plasmid alone. Cell mediated responses to HIV-1 p24 occurred, but were not significantly augmented by delivering the DNA as a VP1 complex. We have consequently for the first time shown a carrier/adjuvant effect of polyomavirus pseudocapsids that strongly increased the humoral immune response in DNA immunization.Entities:
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Year: 2003 PMID： 12744856 DOI： 10.1016/s0264-410x(03)00049-5
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641