Literature DB >> 12744312

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases.

Annabelle Varrot1, James Macdonald, Robert V Stick, Gavin Pell, Harry J Gilbert, Gideon J Davies.   

Abstract

A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

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Year:  2003        PMID： 12744312     DOI： 10.1039/b301592k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Product binding varies dramatically between processive and nonprocessive cellulase enzymes.

Authors:  Lintao Bu; Mark R Nimlos; Michael R Shirts; Jerry Ståhlberg; Michael E Himmel; Michael F Crowley; Gregg T Beckham
Journal:  J Biol Chem       Date:  2012-05-30       Impact factor: 5.157

2.  Crystal structure of glycoside hydrolase family 55 {beta}-1,3-glucanase from the basidiomycete Phanerochaete chrysosporium.

Authors:  Takuya Ishida; Shinya Fushinobu; Rie Kawai; Motomitsu Kitaoka; Kiyohiko Igarashi; Masahiro Samejima
Journal:  J Biol Chem       Date:  2009-02-04       Impact factor: 5.157

3.  A family of thermostable fungal cellulases created by structure-guided recombination.

Authors:  Pete Heinzelman; Christopher D Snow; Indira Wu; Catherine Nguyen; Alan Villalobos; Sridhar Govindarajan; Jeremy Minshull; Frances H Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-23       Impact factor: 11.205

4.  SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability.

Authors:  Pete Heinzelman; Christopher D Snow; Matthew A Smith; Xinlin Yu; Arvind Kannan; Kevin Boulware; Alan Villalobos; Sridhar Govindarajan; Jeremy Minshull; Frances H Arnold
Journal:  J Biol Chem       Date:  2009-07-22       Impact factor: 5.157

5.  Loop motions important to product expulsion in the Thermobifida fusca glycoside hydrolase family 6 cellobiohydrolase from structural and computational studies.

Authors:  Miao Wu; Lintao Bu; Thu V Vuong; David B Wilson; Michael F Crowley; Mats Sandgren; Jerry Ståhlberg; Gregg T Beckham; Henrik Hansson
Journal:  J Biol Chem       Date:  2013-09-30       Impact factor: 5.157

Review 6.  Dissecting conformational contributions to glycosidase catalysis and inhibition.

Authors:  Gaetano Speciale; Andrew J Thompson; Gideon J Davies; Spencer J Williams
Journal:  Curr Opin Struct Biol       Date:  2014-07-10       Impact factor: 6.809
  6 in total

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