BACKGROUND: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. METHODS: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. RESULTS: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinarily on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. CONCLUSIONS: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
BACKGROUND: Individuals with obsessive-compulsive disorder (OCD) frequently have other psychiatric disorders. This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups. METHODS: The study included 450 subjects, case and control probands and their first-degree relatives, and LCA was used to derive empirically based subgroups of 10 disorders: OCD, obsessive-compulsive personality disorder (OCPD), recurrent major depressive disorder (RMDD), separation anxiety disorder, panic disorder or agoraphobia (PD/AG), tic disorders (TD), generalized anxiety disorder (GAD), somatoform disorders (hypochondriasis or body dysmorphic disorder), pathologic skin picking or nail biting (PSP/NB), and eating disorders (EDs). The derived classes were compared on several clinical variables. RESULTS: The best fitting model is a four-class structure: minimal disorder, predominant RMDD and GAD, "highly comorbid," and PD/AG and TD. The nature and number of disorders represented suggests that the first classes are distributed ordinarily on a dimension of severity, and the fourth class is qualitatively distinct. Support for this structure is based on the number of disorders, age at onset of OCD, neuroticism, and extraversion. CONCLUSIONS: In this OCD enriched sample, LCA identified four classes of disorder. These classes appear to conform to two subgroups that may prove useful in investigating the etiology of OCD.
Authors: Stephen Correia; Emily Hubbard; Jason Hassenstab; Agustin Yip; Josef Vymazal; Vit Herynek; Jay Giedd; Dennis L Murphy; Benjamin D Greenberg Journal: Brain Imaging Behav Date: 2009-12-12 Impact factor: 3.978
Authors: Mulugeta Gebregziabher; Matthew S Shotwell; Jane M Charles; Joyce S Nicholas Journal: Comput Stat Data Anal Date: 2012-01-01 Impact factor: 1.681
Authors: Robert R Althoff; Ana V Kuny-Slock; Frank C Verhulst; James J Hudziak; Jan van der Ende Journal: J Child Psychol Psychiatry Date: 2014-03-26 Impact factor: 8.982
Authors: G Nestadt; C Z Di; M A Riddle; M A Grados; B D Greenberg; A J Fyer; J T McCracken; S L Rauch; D L Murphy; S A Rasmussen; B Cullen; A Pinto; J A Knowles; J Piacentini; D L Pauls; O J Bienvenu; Y Wang; K Y Liang; J F Samuels; K Bandeen Roche Journal: Psychol Med Date: 2008-12-02 Impact factor: 7.723
Authors: Ana V Kuny; Robert R Althoff; William Copeland; Meike Bartels; C E M Van Beijsterveldt; Julie Baer; James J Hudziak Journal: J Am Acad Child Adolesc Psychiatry Date: 2013-01-03 Impact factor: 8.829