OBJECTIVE: Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who have had of placental abruption during pregnancy. DESIGN: A retrospective case-control study. SETTING: University Hospital MAS, Malmö, Sweden. METHODS: A comparison of 102 women with placental abruption with 2371 prospectively collected controls. Carriership of FV Leiden was determined and the women were interviewed. MAIN OUTCOME MEASURES: Proportion of FV Leiden carriership, first degree heritage of thrombosis and previous placental abruption in cases and controls. RESULTS: Carriage of FV Leiden was found in 15.7% of women who have had placental abruption as compared with 10.8% of controls (P = 0.12, odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.9-2.7). Around 20% of women with placental abruption reported first degree heritage for venous thrombosis, as compared with 6.7% of controls (P < or = 0.001). CONCLUSIONS: FV Leiden carriership was not significantly different in women with placental abruption. However, there was an increased prevalence of first degree heritage for venous thrombosis in women with placental abruption, indicating a higher prevalence of thrombophilia among women with placental abruption.
OBJECTIVE: Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who have had of placental abruption during pregnancy. DESIGN: A retrospective case-control study. SETTING: University Hospital MAS, Malmö, Sweden. METHODS: A comparison of 102 women with placental abruption with 2371 prospectively collected controls. Carriership of FV Leiden was determined and the women were interviewed. MAIN OUTCOME MEASURES: Proportion of FV Leiden carriership, first degree heritage of thrombosis and previous placental abruption in cases and controls. RESULTS: Carriage of FV Leiden was found in 15.7% of women who have had placental abruption as compared with 10.8% of controls (P = 0.12, odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.9-2.7). Around 20% of women with placental abruption reported first degree heritage for venous thrombosis, as compared with 6.7% of controls (P < or = 0.001). CONCLUSIONS: FV Leiden carriership was not significantly different in women with placental abruption. However, there was an increased prevalence of first degree heritage for venous thrombosis in women with placental abruption, indicating a higher prevalence of thrombophilia among women with placental abruption.
Authors: Grażyna Adler; Jeremy S C Clark; Beata Loniewska; Ewa Czerska; Nermin N Salkic; Andrzej Ciechanowicz Journal: Bosn J Basic Med Sci Date: 2012-05 Impact factor: 3.363
Authors: Catalin S Buhimschi; Frederik Schatz; Graciela Krikun; Irina A Buhimschi; Charles J Lockwood Journal: Expert Rev Mol Med Date: 2010-11-01 Impact factor: 5.600
Authors: Tammy T Shen; Emily A DeFranco; David M Stamilio; Jen Jen Chang; Louis J Muglia Journal: BMC Pregnancy Childbirth Date: 2008-09-12 Impact factor: 3.007