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Literature DB >> 12742164

In or out? The dynamics of Smad nucleocytoplasmic shuttling.

Abstract

Members of the TGF-beta family of growth factors mediate their effects through activation of intracellular Smad proteins, which form transcriptionally competent complexes that accumulate in the nucleus. Recently, several reports have demonstrated that Smads actively shuttle between the cytoplasm and nucleus by distinct mechanisms. Here, we summarize what is known about the dynamics of Smad localization and suggest reasons why nucleocytoplasmic shuttling might be important for proper signal transduction.

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Year: 2003 PMID： 12742164 DOI： 10.1016/s0962-8924(03)00075-8

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

23 in total

1. The second open reading frame of the avian reovirus S1 gene encodes a transcription-dependent and CRM1-independent nucleocytoplasmic shuttling protein.

Authors: Celina Costas; José Martínez-Costas; Gustavo Bodelón; Javier Benavente
Journal: J Virol Date: 2005-02 Impact factor: 5.103

2. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation.

Authors: Yulan Zhao; Mu Xiao; Baoguo Sun; Zhengmao Zhang; Tao Shen; Xueyan Duan; Paul Borchyung Yu; Xin-Hua Feng; Xia Lin
Journal: J Biol Chem Date: 2014-08-06 Impact factor: 5.157

In or out? The dynamics of Smad nucleocytoplasmic shuttling.

1. The second open reading frame of the avian reovirus S1 gene encodes a transcription-dependent and CRM1-independent nucleocytoplasmic shuttling protein.

2. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation.

Review 3. Ubiquitin-dependent regulation of TGFbeta signaling in cancer.

4. Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

5. Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.

6. TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.

7. Chondrosarcoma cell differentiation.

Review 8. TGF-β Signaling from Receptors to Smads.

9. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.

10. Preferential utilization of Imp7/8 in nuclear import of Smads.