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Literature DB >> 12741078

Serum level of the circulating angiogenesis inhibitor endostatin in patients with hyperthyroidism or hypothyroidism.

Eugene J Kucharz¹, Anna Kotulska, Magdalena Kopeć, Barbara Stawiarska-Pieta, Robert Pieczyrak.

Abstract

Serum level of endostatin, a natural angiogenesis inhibitor, was measured in 12 patients with hyperthyroidism and 9 patients with hypothyroidism. Control values were obtained from 12 healthy individuals. Hyperthyroidism was shown to be associated with an increased level of endostatin and hypothyroidism with a decreased endostatin level. There was no correlation of serum endostatin with thyroid hormone levels. Endostatin is a fragment of type XVIII collagen, and it is possible that reported changes are related to the effect of thyroid hormones on connective tissue metabolism.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12741078 DOI： 10.1007/bf03040306

Source DB: PubMed Journal: Wien Klin Wochenschr ISSN： 0043-5325 Impact factor: 1.704

17 in total

Review 1. Collagens and collagen-related diseases.

Authors: J Myllyharju; K I Kivirikko
Journal: Ann Med Date: 2001-02 Impact factor: 4.709

Review 2. Hormonal control of collagen metabolism--Part I.

Authors: E J Kucharz
Journal: Endocrinologie Date: 1988 Apr-Jun

3. Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage IV clear cell renal cancer.

Authors: A L Feldman; L Tamarkin; G F Paciotti; B W Simpson; W M Linehan; J C Yang; W E Fogler; E M Turner; H R Alexander; S K Libutti
Journal: Clin Cancer Res Date: 2000-12 Impact factor: 12.531

4. Serum endostatin levels are elevated in patients with soft tissue sarcoma.

Authors: A L Feldman; H Pak; J C Yang; H R Alexander; S K Libutti
Journal: Cancer Date: 2001-04-15 Impact factor: 6.860

5. Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins.

Authors: S P Oh; Y Kamagata; Y Muragaki; S Timmons; A Ooshima; B R Olsen
Journal: Proc Natl Acad Sci U S A Date: 1994-05-10 Impact factor: 11.205

Serum level of the circulating angiogenesis inhibitor endostatin in patients with hyperthyroidism or hypothyroidism.

Review 1. Collagens and collagen-related diseases.

Review 2. Hormonal control of collagen metabolism--Part I.

3. Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage IV clear cell renal cancer.

4. Serum endostatin levels are elevated in patients with soft tissue sarcoma.

5. Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins.

6. Secreted cathepsin L generates endostatin from collagen XVIII.

7. Generation and degradation of human endostatin proteins by various proteinases.

Review 8. Collagen XVIII/endostatin structure and functional role in angiogenesis.

9. Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution.

10. Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis.

1. Serum endostatin levels in patients with metastatic and non-metastatic well-differentiated thyroid cancer.