| Literature DB >> 12740581 |
Stephanie Bissière1, Yann Humeau, Andreas Lüthi.
Abstract
Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12740581 DOI： 10.1038/nn1058
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884