Barbara Wildhaber1,2, Felix Niggli3, Eva Bergsträsser3, Thomas Stallmach4, Peter Sacher5. 1. Department of Surgery, University Children's Hospital, Zurich, Switzerland. bwildhab@med.umich.edu. 2. Section of Pediatric Surgery, University of Michigan Hospitals, Mott F3970, 0245, MI 48109, Ann Arbor, USA. bwildhab@med.umich.edu. 3. Department of Oncology, University Children's Hospital, Zurich, Switzerland. 4. Department of Pathology, University Hospital of Zurich, Zurich, Switzerland. 5. Department of Surgery, University Children's Hospital, Zurich, Switzerland.
Abstract
UNLABELLED: A paraneoplastic syndrome is occasionally the first clinical symptom seen with tumours. We report on two children who initially presented with paraneoplastic syndromes due to ganglioneuroblastomas: the first with severe watery diarrhoea caused by a ganglioneuroma producing vasoactive intestinal peptide, the second with non-treatable constipation, caused by ganglioneuroma-produced anti-neuronal nuclear antibodies. CONCLUSION: Either severe diarrhoea or chronic constipation may represent rare paraneoplastic syndromes in ganglioneuroblastomas.
UNLABELLED: A paraneoplastic syndrome is occasionally the first clinical symptom seen with tumours. We report on two children who initially presented with paraneoplastic syndromes due to ganglioneuroblastomas: the first with severe watery diarrhoea caused by a ganglioneuroma producing vasoactive intestinal peptide, the second with non-treatable constipation, caused by ganglioneuroma-produced anti-neuronal nuclear antibodies. CONCLUSION: Either severe diarrhoea or chronic constipation may represent rare paraneoplastic syndromes in ganglioneuroblastomas.
Authors: Dannis G van Vuurden; Frans B Plötz; Miranda de Jong; Arend Bokenkamp; Joanna A E van Wijk Journal: Pediatr Nephrol Date: 2005-08-24 Impact factor: 3.714