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Literature DB >> 12738651

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4.

Philipp H Reichel¹, Christine Seemann, Elena Csernok, Jens-M Schröder, Antje Müller, Wolfgang L Gross, Hendrik Schultz.

Abstract

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.

Entities: Gene Species

Mesh：

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Year: 2003 PMID： 12738651 PMCID： PMC154976 DOI： 10.1128/cdli.10.3.473-475.2003

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

15 in total

1. Clinical evaluation of atopic hand-foot dermatitis.

Authors: H J Lee; S J Ha; W K Ahn; D Kim; Y M Park; D G Byun; J W Kim
Journal: Pediatr Dermatol Date: 2001 Mar-Apr Impact factor: 1.588

Review 2. Immunity at the surface: homeostatic mechanisms of the skin immune system.

Authors: I R Williams; T S Kupper
Journal: Life Sci Date: 1996 Impact factor: 5.037

3. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

Authors: J Weiss; P Elsbach; I Olsson; H Odeberg
Journal: J Biol Chem Date: 1978-04-25 Impact factor: 5.157

4. An experimental study to determine the effects of Dermagraft on skin graft viability in the presence of bacterial wound contamination.

Authors: T P Economou; M D Rosenquist; R W Lewis; G P Kealey
Journal: J Burn Care Rehabil Date: 1995 Jan-Feb

5. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.

Authors: Volaluck Supajatura; Hiroko Ushio; Atsuhito Nakao; Shizuo Akira; Ko Okumura; Chisei Ra; Hideoki Ogawa
Journal: J Clin Invest Date: 2002-05 Impact factor: 14.808

6. Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia.

Authors: Geraldine Canny; Ofer Levy; Glenn T Furuta; Sailaja Narravula-Alipati; Richard B Sisson; Charles N Serhan; Sean P Colgan
Journal: Proc Natl Acad Sci U S A Date: 2002-03-12 Impact factor: 11.205

7. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity.

Authors: M N Marra; C G Wilde; J E Griffith; J L Snable; R W Scott
Journal: J Immunol Date: 1990-01-15 Impact factor: 5.422

8. Measurement of bactericidal/permeability-increasing protein in human body fluids by sandwich ELISA.

Authors: M L White; J K Ma; C A Birr; P W Trown; S F Carroll
Journal: J Immunol Methods Date: 1994-01-03 Impact factor: 2.303

9. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.

Authors: S T O'Sullivan; J A Lederer; A F Horgan; D H Chin; J A Mannick; M L Rodrick
Journal: Ann Surg Date: 1995-10 Impact factor: 12.969

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4.

1. Clinical evaluation of atopic hand-foot dermatitis.

Review 2. Immunity at the surface: homeostatic mechanisms of the skin immune system.

3. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

4. An experimental study to determine the effects of Dermagraft on skin graft viability in the presence of bacterial wound contamination.

5. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.

6. Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia.

7. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity.

8. Measurement of bactericidal/permeability-increasing protein in human body fluids by sandwich ELISA.

9. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.

Review 10. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases.

Review 1. The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease.

Review 2. Bacteria in the intestine, helpful residents or enemies from within?

3. Human antimicrobial proteins in ear wax.

Review 4. Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions.