| Literature DB >> 12738095 |
Quan Le Tran1, Yasuhiro Tezuka, Jun-ya Ueda, Nhan Trung Nguyen, Yukiko Maruyama, Khurshida Begum, Hye-Sook Kim, Yusuke Wataya, Qui Kim Tran, Shigetoshi Kadota.
Abstract
Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC(50) values less than 10 microg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC(50) value of 0.5 microg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.Entities:
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Year: 2003 PMID： 12738095 DOI： 10.1016/s0378-8741(03)00045-x
Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360