Literature DB >> 12737598

Synthesis of pentacyclic 13-azadibenzo[a,de]anthracenes via anionic cascade ring closure.

Jesper L Kristensen1, Per Vedsø, Mikael Begtrup.   

Abstract

Bromine-lithium exchange using tert-butyllithium at -78 degrees C initiates a cascade process whereby either xanthone derivatives or pentacyclic 13-azadibenzo[a,de]anthracenes are produced in high yields. The reaction proceeds via a sequential intramolecular trapping of organolithium intermediates.

Entities:  

Year:  2003        PMID： 12737598     DOI： 10.1021/jo0300340

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.

Authors:  Emmanuelle Dubost; Noé Dumas; Christine Fossey; Rosa Magnelli; Sabrina Butt-Gueulle; Céline Ballandonne; Daniel H Caignard; Fabienne Dulin; Jana Sopkova de-Oliveira Santos; Philippe Millet; Yves Charnay; Sylvain Rault; Thomas Cailly; Frederic Fabis
Journal:  J Med Chem       Date:  2012-11-09       Impact factor: 7.446

2.  Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids.

Authors:  Benedikt C Melzer; Alois Plodek; Franz Bracher
Journal:  Beilstein J Org Chem       Date:  2019-09-26       Impact factor: 2.883
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.