Jun-Ki Min1, Chul-Soo Cho, Ho-Youn Kim, Eun-Ji Oh. 1. Holy Family Hospital, College of Medicine, The Catholic University of Korea, Kyunggi-Do, South Korea. min6403@netian.com
Abstract
OBJECTIVE: Peripheral neutrophilia is one of characteristic laboratory findings in patients with adult Still's disease (ASD). We performed this study to identify the bone marrow findings in patients ASD. METHODS: We examined 12 bone marrow biopsy specimens from patients with ASD. RESULTS: The most frequent finding was granulocyte hyperplasia (12/12, 100%) and hypercellularity was observed in 75.0% (8/12) of patients. Plasmacytosis was present in 8.3% (1/12) of specimens. Histiocytosis and reactive hemophagocytosis were found in 25.0% (4/12) and in 16.7% (2/12) respectively. CONCLUSION: Our results show that bone marrow granulocyte hyperplasia is the main possible mechanism for peripheral neutrophilia and that histiocytic activation is a not infrequent bone marrow findings in patients with ASD.
OBJECTIVE:Peripheral neutrophilia is one of characteristic laboratory findings in patients with adult Still's disease (ASD). We performed this study to identify the bone marrow findings in patientsASD. METHODS: We examined 12 bone marrow biopsy specimens from patients with ASD. RESULTS: The most frequent finding was granulocyte hyperplasia (12/12, 100%) and hypercellularity was observed in 75.0% (8/12) of patients. Plasmacytosis was present in 8.3% (1/12) of specimens. Histiocytosis and reactive hemophagocytosis were found in 25.0% (4/12) and in 16.7% (2/12) respectively. CONCLUSION: Our results show that bone marrow granulocyte hyperplasia is the main possible mechanism for peripheral neutrophilia and that histiocytic activation is a not infrequent bone marrow findings in patients with ASD.
Authors: Paul R J Ames; Emily Walker; Darren Aw; David Marshall; Francois de Villiers; Manfred Staber Journal: Clin Rheumatol Date: 2008-10-07 Impact factor: 2.980
Authors: Sergio A Mora Alfonso; Daniel M Cuestas Rodríguez; John D Londoño; Rafael Valle-Oñate; Gerardo Quintana Journal: Springerplus Date: 2015-04-10