| Literature DB >> 12736729 |
Ingrid L Kwee1, Tsutomu Nakada.
Abstract
Dorsolateral prefrontal cortex (DLPF) activation in response to cognitive paradigms engaging working memory was quantitatively evaluated using functional near infrared spectroscopy (fNIRS) in cognitively normal individuals across the age spectrum (20-90 years; 8 females, 52 males). DLPF activation score (DAS) demonstrated a significant decline (r(2) = -0561, p < 0.05) as a function of age. The study indicates that blood flow response associated with DLPF activation declines as a function of age in cognitively normal individuals and that fNIRS can be used as a convenient, portable tool for assessing such activation.Mesh:
Year: 2003 PMID: 12736729 DOI: 10.1007/s00415-003-1028-x
Source DB: PubMed Journal: J Neurol ISSN: 0340-5354 Impact factor: 4.849