Literature DB >> 12736461

Six new andrographolide metabolites in rats.

Xiangjiu He1, Jiankuan Li, Hao Gao, Feng Qiu, Xiangmin Cui, Xinsheng Yao.   

Abstract

Six new andrographolide metabolites M-5-M-10 were isolated from rat urine, feces, and the contents of the small intestine. Three (M-5-M-7) as sulfate ester compounds were identified as new compounds. The structures of these six metabolites were determined to be 14-deoxy-12(R)-sulfo andrographolide 3-sulfate (M-5), 14-deoxy-12(S)-sulfo andrographolide 3-sulfate (M-6), 14-sulfo isoandrographolide 3-sulfate (M-7), 14-deoxy-11,12-didehydroandrographolide (M-8), isoandrographolide (M-9), and 14-deoxy andrographolide (M-10), respectively, based on chemical evidence and spectroscopic analysis.

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Year:  2003        PMID： 12736461     DOI： 10.1248/cpb.51.586

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  5 in total

1.  Identification of sulfation sites of metabolites and prediction of the compounds' biological effects.

Authors:  Lin Yi; Joe Dratter; Chao Wang; Jon A Tunge; Heather Desaire
Journal:  Anal Bioanal Chem       Date:  2006-05-25       Impact factor: 4.142

2.  Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia.

Authors:  Su Jing Chan; W S Fred Wong; Peter T H Wong; Jin-Song Bian
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

3.  Andrographis paniculata elicits anti-invasion activities by suppressing TM4SF3 gene expression and by anoikis-sensitization in esophageal cancer cells.

Authors:  Grace Gar-Lee Yue; Julia Kin-Ming Lee; Lin Li; Kar-Man Chan; Eric Chun-Wai Wong; Judy Yuet-Wah Chan; Kwok-Pui Fung; Vivian Wai Yan Lui; Philip Wai-Yan Chiu; Clara Bik-San Lau
Journal:  Am J Cancer Res       Date:  2015-11-15       Impact factor: 6.166

Review 4.  A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease.

Authors:  Phanit Songvut; Tawit Suriyo; Duangchit Panomvana; Nuchanart Rangkadilok; Jutamaad Satayavivad
Journal:  Front Pharmacol       Date:  2022-08-19       Impact factor: 5.988

5.  Role of semi-purified andrographolide from Andrographis paniculata extract as nano-phytovesicular carrier for enhancing oral absorption and hypoglycemic activity.

Authors:  Vinod Kumar Verma; Md Kamaruz Zaman; Shekhar Verma; Santosh Kumar Verma; Khomendra Kumar Sarwa
Journal:  Chin Herb Med       Date:  2019-12-25
  5 in total

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