Literature DB >> 12735907

Analysis of mortality decline along with age and latent congenital defects.

Josef Dolejs1.   

Abstract

Mortality from congenital anomalies is inversely proportional to age after the age of 1 year. The theory of congenital individual risk explains this mortality decline. The overall aim of this study is to test whether the theory describes mortality decline for all diseases within the first year of life and after the age of 1. Mortality decline along with age was analyzed in five countries and for all causes of death. The theory of congenital individual risk describes well the real mortality decline for all diseases except malignant neoplasms after the birth. Decline of mortality is due to the dying out of the more impaired individuals. Mortality decline with the first power of age results from the selection before the birth. It is dominant and the frequency of defects decreases proportionally to the value of individual risk of death. In the case of identically probable defects, the selection does not occur and mortality declines with the square of age. Congenital defects were also identified as a cause of death in the case of infectious diseases occurring before the age of 10. Mortality from malignant neoplasms is age-independent within the age period 1-20 years and, contrary to all other diseases, no small subpopulation with a significant individual risk was identified.

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Year:  2003        PMID: 12735907     DOI: 10.1016/s0047-6374(03)00063-0

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  5 in total

1.  Decrease of total activity with time at long distances from a nuclear accident or explosion.

Authors:  Josef Dolejs
Journal:  Radiat Environ Biophys       Date:  2005-04-08       Impact factor: 1.925

2.  Onset of mortality increase with age and age trajectories of mortality from all diseases in the four Nordic countries.

Authors:  Josef Dolejs; Petra Marešová
Journal:  Clin Interv Aging       Date:  2017-01-21       Impact factor: 4.458

3.  Database of age trajectories of mortality in 110 countries and web application: Data report.

Authors:  Josef Dolejs
Journal:  Front Public Health       Date:  2022-07-29

4.  Modeling the Age-Associated Decrease in Mortality Rate for Congenital Anomalies of the Central Nervous System Using WHO Metadata From Nine European Countries.

Authors:  Josef Dolejs; Helena Homolkova; Petra Maresova
Journal:  Front Neurol       Date:  2018-07-19       Impact factor: 4.003

5.  Why Does Child Mortality Decrease With Age? Modeling the Age-Associated Decrease in Mortality Rate Using WHO Metadata From 14 European Countries.

Authors:  Josef Dolejs; Helena Homolková
Journal:  Front Pediatr       Date:  2020-10-27       Impact factor: 3.418

  5 in total

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