Literature DB >> 12735683

Synthesis and cytotoxicity of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide.

Sejin Lim1, Jae Hark Ryu, Chaeuk Im, Chul Bu Yim.   

Abstract

A series of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide was synthesized and evaluated for their in vitro cytotoxic activity against five human tumor cell lines. The urea analogue (2b) of B13 showed comparable or slightly more potent cytotoxic activity as compared to B13, indicating that urea does appear to serve as a bioisostere of amide.

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Year:  2003        PMID： 12735683     DOI： 10.1007/bf02976954

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  3 in total

Review 1.  Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.

Authors:  Shikha Kumari; Angelica V Carmona; Amit K Tiwari; Paul C Trippier
Journal:  J Med Chem       Date:  2020-08-04       Impact factor: 7.446

2.  Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.

Authors:  Zdzislaw M Szulc; Nalini Mayroo; AiPing Bai; Jacek Bielawski; Xiang Liu; James S Norris; Yusuf A Hannun; Alicja Bielawska
Journal:  Bioorg Med Chem       Date:  2007-08-24       Impact factor: 3.641

Review 3.  Urea-based anticancer agents. Exploring 100-years of research with an eye to the future.

Authors:  Roberta Listro; Giacomo Rossino; Federica Piaggi; Falilat Folasade Sonekan; Daniela Rossi; Pasquale Linciano; Simona Collina
Journal:  Front Chem       Date:  2022-09-15       Impact factor: 5.545
  3 in total

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