Literature DB >> 12734766

Methylphenidate enhances both intracortical inhibition and facilitation in healthy adults.

J Kirschner1, G H Moll, U M Fietzek, H Heinrich, V Mall, S Berweck, F Heinen, A Rothenberger.   

Abstract

Transcranial magnetic stimulation was used to investigate the effect of the psychostimulant drug methylphenidate (MPH) on motor cortex excitability in healthy adults (n = 12) in a placebo-controlled, crossover design study. MPH caused an enhancement of intracortical inhibition as well as intracortical facilitation. Enhancement of both of these TMS parameters was unexpected and suggests that MPH exerts its action on the motor cortex not only through the dopaminergic neurotransmitter system.

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Year:  2003        PMID： 12734766     DOI： 10.1055/s-2003-39049

Source DB:  PubMed          Journal:  Pharmacopsychiatry        ISSN： 0176-3679            Impact factor:   5.788


  16 in total

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2.  Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons.

Authors:  Kimberly R Urban; Barry D Waterhouse; Wen-Jun Gao
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3.  Neurophysiological assessment of fatigue in electrical injury patients.

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Review 4.  The use of non-invasive brain stimulation techniques to facilitate recovery from post-stroke aphasia.

Authors:  Gottfried Schlaug; Sarah Marchina; Catherine Y Wan
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5.  Modulation of motorcortical excitability by methylphenidate in adult voluntary test persons performing a go/nogo task.

Authors:  Johannes Buchmann; A Dueck; W Gierow; H Zamorski; S Heinicke; H Heinrich; J Hoeppner; T Klauer; O Reis; F Haessler
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6.  Intracortical motor inhibition and facilitation in adults with attention deficit/hyperactivity disorder.

Authors:  Jacqueline Hoeppner; Martin Neumeyer; Roland Wandschneider; Sabine C Herpertz; Wolfgang Gierow; Frank Haessler; Johannes Buchmann
Journal:  J Neural Transm (Vienna)       Date:  2008-11-06       Impact factor: 3.575

7.  Impaired transcallosally mediated motor inhibition in adults with attention-deficit/hyperactivity disorder is modulated by methylphenidate.

Authors:  Jacqueline Hoeppner; Roland Wandschneider; Martin Neumeyer; Wolfgang Gierow; Frank Haessler; Sabine C Herpertz; Johannes Buchmann
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Review 9.  Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research.

Authors:  Lindsay M Oberman; Peter G Enticott; Manuel F Casanova; Alexander Rotenberg; Alvaro Pascual-Leone; James T McCracken
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10.  Effects of methylphenidate on motor system excitability in a response inhibition task.

Authors:  Oliver Kratz; Martin S Diruf; Petra Studer; Wolfgang Gierow; Johannes Buchmann; Gunther H Moll; Hartmut Heinrich
Journal:  Behav Brain Funct       Date:  2009-02-27       Impact factor: 3.759
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