Literature DB >> 12734754

Pleomorph poorly differentiated endocrine carcinoma of the rectum.

Pellegrino Crafa1, Massimo Milione, Cinzia Azzoni, Francesco Paolo Pilato, Silvia Pizzi, Cesare Bordi.   

Abstract

We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.

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Year:  2003        PMID： 12734754     DOI： 10.1007/s00428-003-0807-1

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


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