Literature DB >> 12734263

Kinetics and significance of serum hepatitis C virus core antigen in patients with acute hepatitis C.

Agostino Cividini1, Antonella Cerino, Alba Muzzi, Milena Furione, Chiara Rebucci, Laura Segagni, Marta Gatti, Vincenzo Barnaba, Mario U Mondelli.   

Abstract

An immunoassay detecting hepatitis C virus core antigen was evaluated for its ability to predict clinical outcome in a series of patients with acute hepatitis C. In subjects who cleared the virus, core antigen was no longer detectable within 16 weeks of onset, whereas considerable fluctuations were noted among patients progressing to chronic hepatitis, one of whom showed consistently negative values despite the intermittent presence of viral RNA.

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Year:  2003        PMID： 12734263      PMCID： PMC154695          DOI： 10.1128/JCM.41.5.2144-2146.2003

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

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Authors:  A M Di Bisceglie
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Review 2.  Natural history of hepatitis C.

Authors:  A Alberti; L Chemello; L Benvegnù
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Authors:  M Vogt; T Lang; G Frösner; C Klingler; A F Sendl; A Zeller; B Wiebecke; B Langer; H Meisner; J Hess
Journal:  N Engl J Med       Date:  1999-09-16       Impact factor: 91.245

4.  Detection of hepatitis C core antigen in serum or plasma as a marker of hepatitis C viraemia in the serological window-phase.

Authors:  A Widell; V Molnegren; F Pieksma; M Calmann; J Peterson; S R Lee
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5.  Treatment of acute hepatitis C with interferon alfa-2b.

Authors:  E Jaeckel; M Cornberg; H Wedemeyer; T Santantonio; J Mayer; M Zankel; G Pastore; M Dietrich; C Trautwein; M P Manns
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6.  Novel approach to reduce the hepatitis C virus (HCV) window period: clinical evaluation of a new enzyme-linked immunosorbent assay for HCV core antigen.

Authors:  G Icardi; F Ansaldi; B M Bruzzone; P Durando; S Lee; C de Luigi; P Crovari
Journal:  J Clin Microbiol       Date:  2001-09       Impact factor: 5.948

7.  Evaluation of a new enzyme immunoassay for hepatitis C virus (HCV) core antigen with clinical sensitivity approximating that of genomic amplification of HCV RNA.

Authors:  E Tanaka; C Ohue; K Aoyagi; K Yamaguchi; S Yagi; K Kiyosawa; H J Alter
Journal:  Hepatology       Date:  2000-08       Impact factor: 17.425

8.  The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team.

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9.  Virological features of hepatitis C virus infection in hemodialysis patients.

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10.  Clinical utility of total HCV core antigen quantification: a new indirect marker of HCV replication.

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  5 in total

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Journal:  J Clin Microbiol       Date:  2005-01       Impact factor: 5.948

2.  Evaluation of the core antigen assay as a second-line supplemental test for diagnosis of active hepatitis C virus infection.

Authors:  Mel Krajden; Rishma Shivji; Kingsley Gunadasa; Annie Mak; Gail McNabb; Michel Friesenhahn; David Hendricks; Lorraine Comanor
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3.  Monitoring response to antiviral therapy for patients with chronic hepatitis C virus infection by a core-antigen assay.

Authors:  Chiara Rebucci; Antonella Cerino; Agostino Cividini; Letizia Timo; Milena Furione; Mario U Mondelli
Journal:  J Clin Microbiol       Date:  2003-08       Impact factor: 5.948

4.  Hepatitis C virus core and NS3 antigens induced conjunctival inflammation via toll-like receptor-mediated signaling.

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5.  Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation.

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  5 in total

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