Literature DB >> 12733311

[Botulism toxin, bioterrorist weapon].

Philippe Bossi1, François Bricaire.   

Abstract

BOTULISM AND BIOWARFARE: Botulism is a severe neuro-paralysing infection due to a toxin produced by Clostridium botulinum. The use of the botulinum toxin for terrorist aims in the form of aerosols is a perfectly credible eventuality. The botulinum toxin is the most potent toxin known; it is easy to produce and can lead to massive destruction. DEPENDING ON THE CONTAMINATION: The clinical forms of botulism depend on the mode of contamination. Botulism through inhalation can only be the result of a deliberate act using an aerosol. The clinical symptomatology is identical to that of the other forms. PREVENTION: In the case of a bio-terrorist attack with an aerosol of botulinum toxin, the subjects exposed should be vaccinated as a prophylactic measure with trivalent antitoxin vaccine (types A, B and E). This vaccine must be administered as rapidly as possible in symptomatic patients. A single case of botulism acquired by inhalation corresponds to an act of terrorism.

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Year:  2003        PMID: 12733311

Source DB:  PubMed          Journal:  Presse Med        ISSN: 0755-4982            Impact factor:   1.228


  3 in total

1.  Unique substrate recognition mechanism of the botulinum neurotoxin D light chain.

Authors:  Jiubiao Guo; Sheng Chen
Journal:  J Biol Chem       Date:  2013-08-19       Impact factor: 5.157

2.  Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25.

Authors:  Sheng Chen; Joseph T Barbieri
Journal:  J Biol Chem       Date:  2011-03-04       Impact factor: 5.157

3.  Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5.

Authors:  Jiubiao Guo; Edward Wai Chi Chan; Sheng Chen
Journal:  Sci Rep       Date:  2016-01-22       Impact factor: 4.379

  3 in total

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