OBJECTIVES: To study the putative role of methadone maintenance treatment in the improvement of life expectancy of opioid addicts. DESIGN: Retrospective longitudinal study. PARTICIPANTS: All 1487 patients receiving methadone maintenance treatment in Alicante between June 1990 and December 1997. STATISTICAL ANALYSIS: Mortality rates were studied using Kaplan-Meier survival curves. Protection or risk factors were analyzed using Cox's proportional hazards model. RESULTS: Mortality rates decreased from 87/1000 in 1991 to 17/1000 in 1997. The following factors influenced mortality: HIV infection [Hazard Ratio (HR)=7, 95% confidence interval (CI)=4-12]; current methadone status (HR=3.2, 95%CI=1.5-7.1) and MMT retention (retained vs. drop-out, HR=0.5, 95%CI=0.2-1.1; re-enrolled vs. drop-out, HR=0.3, 95%CI=0.2-0.5). CONCLUSION: Expediting entry and re-enrolling in methadone maintenance treatment improves survival.
OBJECTIVES: To study the putative role of methadone maintenance treatment in the improvement of life expectancy of opioid addicts. DESIGN: Retrospective longitudinal study. PARTICIPANTS: All 1487 patients receiving methadone maintenance treatment in Alicante between June 1990 and December 1997. STATISTICAL ANALYSIS: Mortality rates were studied using Kaplan-Meier survival curves. Protection or risk factors were analyzed using Cox's proportional hazards model. RESULTS: Mortality rates decreased from 87/1000 in 1991 to 17/1000 in 1997. The following factors influenced mortality: HIV infection [Hazard Ratio (HR)=7, 95% confidence interval (CI)=4-12]; current methadone status (HR=3.2, 95%CI=1.5-7.1) and MMT retention (retained vs. drop-out, HR=0.5, 95%CI=0.2-1.1; re-enrolled vs. drop-out, HR=0.3, 95%CI=0.2-0.5). CONCLUSION: Expediting entry and re-enrolling in methadone maintenance treatment improves survival.
Authors: Catalina Lopez-Quintero; Kimberly B Roth; William W Eaton; Li-Tzy Wu; Linda B Cottler; Martha Bruce; James C Anthony Journal: Drug Alcohol Depend Date: 2015-09-03 Impact factor: 4.492
Authors: Bradley M Mathers; Louisa Degenhardt; Chiara Bucello; James Lemon; Lucas Wiessing; Mathew Hickman Journal: Bull World Health Organ Date: 2013-02-01 Impact factor: 9.408