Literature DB >> 12731003

Markers of cellular proliferation are expressed in cortical tubers.

Allana Lee1, Michelle Maldonado, Marianna Baybis, Christopher A Walsh, Bernd Scheithauer, Raymond Yeung, Jack Parent, Howard L Weiner, Peter B Crino.   

Abstract

p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. Many GCs exhibited HuD and NeuN immunolabeling suggesting a differentiated neural phenotype. Giant cells in tubers, SEGAs and subependymal nodules in the Eker rat model of TSC expressed CRMP4 and DCX. Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells.

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Year:  2003        PMID： 12731003     DOI： 10.1002/ana.10579

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  21 in total

Review 1.  Epilepsy secondary to tuberous sclerosis: lessons learned and current challenges.

Authors:  Romina Moavero; Caterina Cerminara; Paolo Curatolo
Journal:  Childs Nerv Syst       Date:  2010-04-01       Impact factor: 1.475

Review 2.  Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations.

Authors:  Michael Wong
Journal:  Exp Neurol       Date:  2011-10-08       Impact factor: 5.330

3.  Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex.

Authors:  Whitney E Parker; Ksenia A Orlova; Gregory G Heuer; Marianna Baybis; Eleonora Aronica; Michael Frost; Michael Wong; Peter B Crino
Journal:  Am J Pathol       Date:  2010-12-23       Impact factor: 4.307

4.  Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation.

Authors:  Avanita S Prabowo; Jasper J Anink; Martin Lammens; Mark Nellist; Ans M W van den Ouweland; Homa Adle-Biassette; Harvey B Sarnat; Laura Flores-Sarnat; Peter B Crino; Eleonora Aronica
Journal:  Brain Pathol       Date:  2012-08-30       Impact factor: 6.508

Review 5.  The neurobiology of the tuberous sclerosis complex.

Authors:  Leah Marcotte; Peter B Crino
Journal:  Neuromolecular Med       Date:  2006       Impact factor: 3.843

Review 6.  Giant cells: contradiction to two-hit model of tuber formation?

Authors:  Jaroslaw Jozwiak; Sergiusz Jozwiak
Journal:  Cell Mol Neurobiol       Date:  2005-08       Impact factor: 5.046

Review 7.  The tuberous sclerosis complex.

Authors:  Ksenia A Orlova; Peter B Crino
Journal:  Ann N Y Acad Sci       Date:  2010-01       Impact factor: 5.691

8.  Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation.

Authors:  Avery J Zucco; Valentina Dal Pozzo; Alina Afinogenova; Ronald P Hart; Orrin Devinsky; Gabriella D'Arcangelo
Journal:  Mol Cell Neurosci       Date:  2018-08-23       Impact factor: 4.314

9.  The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes.

Authors:  Jerzy Wegiel; Izabela Kuchna; Krzysztof Nowicki; Humi Imaki; Jarek Wegiel; Elaine Marchi; Shuang Yong Ma; Abha Chauhan; Ved Chauhan; Teresa Wierzba Bobrowicz; Mony de Leon; Leslie A Saint Louis; Ira L Cohen; Eric London; W Ted Brown; Thomas Wisniewski
Journal:  Acta Neuropathol       Date:  2010-03-03       Impact factor: 17.088

10.  Semi-automatic volumetry of cortical tubers in tuberous sclerosis complex.

Authors:  Yasuhiro Nakata; Noriko Sato; Ayako Hattori; Kimiteru Ito; Yukio Kimura; Kouhei Kamiya; Yoko Shigemoto; Eiji Nakagawa; Masayuki Sasaki; Kuni Ohtomo
Journal:  Jpn J Radiol       Date:  2013-02-02       Impact factor: 2.374
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