Literature DB >> 12729915

Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers.

Ghiam Yamin1, Vladimir N Uversky, Anthony L Fink.   

Abstract

The aggregation of alpha-synuclein in dopaminergic neurons is a critical factor in the etiology of Parkinson's disease (PD). Oxidative and nitrative stress is also implicated in PD. We examined the effect of nitration on the propensity of alpha-synuclein to fibrillate in vitro. Fibril formation of alpha-synuclein was completely inhibited by nitration, due to the formation of stable soluble oligomers (apparently octamers). More importantly the presence of sub-stoichiometric concentrations of nitrated alpha-synuclein led to inhibition of fibrillation of non-modified alpha-synuclein. These observations suggest that nitration of soluble alpha-synuclein may be a protective factor in PD, rather than a causative one.

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Year:  2003        PMID： 12729915     DOI： 10.1016/s0014-5793(03)00367-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  51 in total

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