| Literature DB >> 12729666 |
Shu-Wei Yang1, Alexei Buivich, Tze-Ming Chan, Michelle Smith, Jean Lachowicz, Shirley A Pomponi, Amy E Wright, Ronald Mierzwa, Mahesh Patel, Vincent Gullo, Min Chu.
Abstract
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a new sterol sulfate Sch 572423 (2). Compounds 1 and 2 were identified as P2Y(12) inhibitors with IC(50) of 0.48 and 2.2 microM, respectively. The general method of purification for the MFL library and the structure elucidation of compound 2 are described.Entities:
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Year: 2003 PMID： 12729666 DOI： 10.1016/s0960-894x(03)00260-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823