Literature DB >> 12729661

Non-imidazole heterocyclic histamine H3 receptor antagonists.

Wenying Chai1, J Guy Breitenbucher, Annette Kwok, Xiaobing Li, Victoria Wong, Nicholas I Carruthers, Timothy W Lovenberg, Curt Mazur, Sandy J Wilson, Frank U Axe, Todd K Jones.   

Abstract

Continued exploration of the SAR around the lead imidazopyridine histamine H(3) antagonist 1 has led to the discovery of several related series of heterocyclic histamine H(3) antagonists. The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12729661     DOI： 10.1016/s0960-894x(03)00299-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Roles of histamine and its receptors in allergic and inflammatory bowel diseases.

Authors:  Hua Xie; Shao-Heng He
Journal:  World J Gastroenterol       Date:  2005-05-21       Impact factor: 5.742

2.  Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated.

Authors:  E A Harper; J W Black
Journal:  Br J Pharmacol       Date:  2007-04-02       Impact factor: 8.739

3.  Silver-Mediated Synthesis of Indolizines via Oxidative C-H functionalization and 5- endo-dig cyclization.

Authors:  Amit N Pandya; James T Fletcher; Eric M Villa; Devendra K Agrawal
Journal:  Tetrahedron Lett       Date:  2014-12-10       Impact factor: 2.415

4.  Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.

Authors:  A J Barbier; C Berridge; C Dugovic; A D Laposky; S J Wilson; J Boggs; L Aluisio; B Lord; C Mazur; C M Pudiak; X Langlois; W Xiao; R Apodaca; N I Carruthers; T W Lovenberg
Journal:  Br J Pharmacol       Date:  2004-10-04       Impact factor: 8.739

5.  (6S,7S,8R,8aS)-6-Ethyl-perhydro-indolizine-7,8-diol.

Authors:  Lubomír Svorc; Viktor Vrábel; Jozefína Zúžiová; Stefan Marchalín; Jozef Kožíšek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-06-16
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.