| Literature DB >> 12729656 |
Robert J Kerns1, Michael J Rybak, Glenn W Kaatz, Flamur Vaka, Raymond Cha, Richard G Grucz, Veena U Diwadkar, Tracey D Ward.
Abstract
The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.Entities:
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Year: 2003 PMID： 12729656 DOI： 10.1016/s0960-894x(03)00208-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823