Literature DB >> 12729642

Synthesis of beta-lactamase activated nitric oxide donors.

Xiaoping Tang1, Tingwei Cai, Peng George Wang.   

Abstract

In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.

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Year:  2003        PMID: 12729642     DOI: 10.1016/s0960-894x(03)00242-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Progress towards a stable cephalosporin-halogenated phenazine conjugate for antibacterial prodrug applications.

Authors:  Tao Xiao; Ke Liu; Robert W Huigens
Journal:  Bioorg Med Chem Lett       Date:  2020-08-27       Impact factor: 2.823

2.  Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug.

Authors:  Ryan M Phelan; Marc Ostermeier; Craig A Townsend
Journal:  Bioorg Med Chem Lett       Date:  2008-12-24       Impact factor: 2.823

  2 in total

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