| Literature DB >> 12729639 |
Peter J Manley1, Adrienne E Balitza, Mark T Bilodeau, Kathleen E Coll, George D Hartman, Rosemary C McFall, Keith W Rickert, Leonard D Rodman, Kenneth A Thomas.
Abstract
2,4-Disubstituted pyrimidines were synthesized as a novel class of KDR kinase inhibitors. Evaluation of the SAR of the screening lead compound 1 (KDR IC(50)=105 nM, Cell IC(50)=8% inhibition at 500 nM) led to the potent 3,5-dimethylaniline derivative 2d (KDR IC(50)=6 nM, cell IC(50)=19 nM).Entities:
Mesh：
Substances：
Year: 2003 PMID： 12729639 DOI： 10.1016/s0960-894x(03)00244-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823