| Literature DB >> 12729636 |
Nakjeong Kim1, Sunkyung Lee, Kyu Yang Yi, Sung-eun Yoo, Guncheol Kim, Chong Ock Lee, Sung Hee Park, Byung Ho Lee.
Abstract
A series of 4-(N-imidazol-2-ylmethyl)aminobenzopyran analogues, originally designed as K(ATP) openers for ischemic diseases, showed antiangiogenic properties through the inhibition of HUVEC tube formation. Especially one of p-Cl substituted analogues (4c) completely inhibited HUVEC tube formation at 10 microM. The compound 4c significantly inhibited tumor growth by 52% on A549 (human non small cell lung carcinoma) in nude mice xenografts without any significant side effects.Entities:
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Year: 2003 PMID： 12729636 DOI： 10.1016/s0960-894x(03)00248-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823