Literature DB >> 12729631

Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors.

Manojit Pal1, Venugopal Rao Veeramaneni, Murali Nagabelli, Srinivas Rao Kalleda, Parimal Misra, Seshagiri Rao Casturi, Koteswar Rao Yeleswarapu.   

Abstract

A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition. Few of them were identified as selective COX-2 inhibitors. Structure-activity relationship studies within the series are discussed.

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Year:  2003        PMID： 12729631     DOI： 10.1016/s0960-894x(03)00282-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  QSAR and classification models of a novel series of COX-2 selective inhibitors: 1,5-diarylimidazoles based on support vector machines.

Authors:  H X Liu; R S Zhang; X J Yao; M C Liu; Z D Hu; B T Fan
Journal:  J Comput Aided Mol Des       Date:  2004-06       Impact factor: 3.686

2.  3,3'-Dibromo-5,5'-bis-[(S)-l-menth-yloxy]-4,4'-(hexane-1,6-diyldiimino)difuran-2(5H)-one.

Authors:  Zhao-Yang Wang; Xiu-Mei Song; Yue-Peng Cai; Zheng-Zhou Mao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-07-31
  2 in total

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