OBJECTIVE: To determine the change in positive, negative, and depressive symptoms after 1 year in an early psychosis program. METHOD: One hundred and eighty subjects were included from the first 257 admissions for a first episode of psychosis to a comprehensive early psychosis program. Most had a diagnosis of schizophrenia or schizophreniform disorder. Subjects were assessed on admission to the program and at 3, 6, and 12 months after admission. All 180 subjects completed the 1-year assessment. Assessment measures included the Positive and Negative Syndrome Scale and the Calgary Depression Scale for Schizophrenia. RESULTS: There was a clinically and statistically significant improvement in positive symptoms by 3 months, depression increased at 3 months but significantly improved by 12 months, and negative symptoms changed little over the first year. CONCLUSIONS: The differential changes in symptoms in the first year after admission have implications for treatment.
OBJECTIVE: To determine the change in positive, negative, and depressive symptoms after 1 year in an early psychosis program. METHOD: One hundred and eighty subjects were included from the first 257 admissions for a first episode of psychosis to a comprehensive early psychosis program. Most had a diagnosis of schizophrenia or schizophreniform disorder. Subjects were assessed on admission to the program and at 3, 6, and 12 months after admission. All 180 subjects completed the 1-year assessment. Assessment measures included the Positive and Negative Syndrome Scale and the Calgary Depression Scale for Schizophrenia. RESULTS: There was a clinically and statistically significant improvement in positive symptoms by 3 months, depression increased at 3 months but significantly improved by 12 months, and negative symptoms changed little over the first year. CONCLUSIONS: The differential changes in symptoms in the first year after admission have implications for treatment.
Authors: Sarah R Uzenoff; David L Penn; Karen A Graham; Sylvia Saade; Barbara B Smith; Diana O Perkins Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2012-01-26 Impact factor: 4.328
Authors: Joseph Ventura; Kenneth L Subotnik; Lisa H Guzik; Gerhard S Hellemann; Michael J Gitlin; Rachel C Wood; Keith H Nuechterlein Journal: Schizophr Res Date: 2011-07-18 Impact factor: 4.939
Authors: Tom K J Craig; Philippa Garety; Paddy Power; Nikola Rahaman; Susannah Colbert; Miriam Fornells-Ambrojo; Graham Dunn Journal: BMJ Date: 2004-10-14