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Literature DB >> 12728643

Lessons for human diabetes from experimental mouse models.

Abstract

A precise knowledge of the defects underlying type 1 and type 2 diabetes is essential for designing appropriate therapeutic strategies. Because experiments in humans are limited, naturally occurring, and especially genetically engineered rodent models, have revolutionized research in diabetes. We review some of the models created recently and discuss their impact on human diabetes.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12728643 DOI： 10.1007/s11892-003-0041-x

Source DB: PubMed Journal: Curr Diab Rep ISSN： 1534-4827 Impact factor: 5.430

70 in total

1. Putting the genes for type II diabetes on the map.

Authors: K Almind; A Doria; C R Kahn
Journal: Nat Med Date: 2001-03 Impact factor: 53.440

Review 2. Mouse models of insulin resistance.

Authors: Marta Letizia Hribal; Francesco Oriente; Domenico Accili
Journal: Am J Physiol Endocrinol Metab Date: 2002-05 Impact factor: 4.310

3. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Authors: C Y Zhang; G Baffy; P Perret; S Krauss; O Peroni; D Grujic; T Hagen; A J Vidal-Puig; O Boss; Y B Kim; X X Zheng; M B Wheeler; G I Shulman; C B Chan; B B Lowell
Journal: Cell Date: 2001-06-15 Impact factor: 41.582

4. Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting.

Authors: Chris Ramsey; Alex Bukrinsky; Leena Peltonen
Journal: Hum Mol Genet Date: 2002-12-15 Impact factor: 6.150

5. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23.

Authors: Edwin Liu; Hiroaki Moriyama; Norio Abiru; Dongmei Miao; Liping Yu; Robert M Taylor; Fred D Finkelman; George S Eisenbarth
Journal: J Clin Invest Date: 2002-10 Impact factor: 14.808

Lessons for human diabetes from experimental mouse models.

1. Putting the genes for type II diabetes on the map.

Review 2. Mouse models of insulin resistance.

3. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

4. Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting.

5. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23.

6. Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice.

7. Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7.

8. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice.

9. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model.

10. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.

Review 1. New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism.

2. Ins1(Cre) knock-in mice for beta cell-specific gene recombination.