Literature DB >> 12727789

Variability and regulation of O6-alkylguanine-DNA alkyltransferase.

Geoffrey P Margison1, Andrew C Povey, Bernd Kaina, Mauro F Santibáñez Koref.   

Abstract

O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

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Year:  2003        PMID： 12727789     DOI： 10.1093/carcin/bgg005

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  56 in total

1.  Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage.

Authors:  Giuseppe Perugino; Antonella Vettone; Giuseppina Illiano; Anna Valenti; Maria C Ferrara; Mosè Rossi; Maria Ciaramella
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

Review 2.  Alkyltransferase-like proteins: molecular switches between DNA repair pathways.

Authors:  Julie L Tubbs; John A Tainer
Journal:  Cell Mol Life Sci       Date:  2010-05-26       Impact factor: 9.261

3.  Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells.

Authors:  Nada Kraguljac Kurtović; Milena Krajnović; Andrija Bogdanović; Nada Suvajdžić; Jelica Jovanović; Bogomir Dimitrijević; Milica Colović; Koviljka Krtolica
Journal:  Med Oncol       Date:  2012-07-07       Impact factor: 3.064

Review 4.  DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas?

Authors:  William M Grady; Cornelia M Ulrich
Journal:  Gut       Date:  2007-03       Impact factor: 23.059

5.  Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.

Authors:  Sahar Javanmard; Natalia A Loktionova; Qingming Fang; Gary T Pauly; Anthony E Pegg; Robert C Moschel
Journal:  J Med Chem       Date:  2007-09-20       Impact factor: 7.446

Review 6.  Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk.

Authors:  Jong Y Park; Yifan Huang; Thomas A Sellers
Journal:  Methods Mol Biol       Date:  2009

7.  Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.

Authors:  Qingming Fang; Anne M Noronha; Sebastian P Murphy; Christopher J Wilds; Julie L Tubbs; John A Tainer; Goutam Chowdhury; F Peter Guengerich; Anthony E Pegg
Journal:  Biochemistry       Date:  2008-09-20       Impact factor: 3.162

8.  Genomic predictors of interindividual differences in response to DNA damaging agents.

Authors:  Rebecca C Fry; J Peter Svensson; Chandni Valiathan; Emma Wang; Brad J Hogan; Sanchita Bhattacharya; James M Bugni; Charles A Whittaker; Leona D Samson
Journal:  Genes Dev       Date:  2008-09-19       Impact factor: 11.361

9.  MRI to MGMT: predicting methylation status in glioblastoma patients using convolutional recurrent neural networks.

Authors:  Lichy Han; Maulik R Kamdar
Journal:  Pac Symp Biocomput       Date:  2018

10.  Expression of O-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients.

Authors:  Abir A Saad; Heba Sh Kassem; Andrew C Povey; Geoffrey P Margison
Journal:  J Nucleic Acids       Date:  2010-10-17
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