Literature DB >> 12726856

Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer.

Eric R Fearon1.   

Abstract

A recent paper in Cell (Fujita et al., 2003) demonstrates that MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, is an estrogen receptor-regulated inhibitor of the Snail zinc finger transcription factor in breast cancer. Given the important role of Snail in repressing E-cadherin transcription and the function of E-cadherin as a tumor suppressor protein and regulator of epithelial architecture, the findings offer potentially significant new insights into cancer pathogenesis.

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Year:  2003        PMID： 12726856     DOI： 10.1016/s1535-6108(03)00087-4

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  27 in total

1.  E-cadherin expression in transitional cell carcinomas.

Authors:  Eszter Székely; Virág Török; Tamás Székely; Péter Riesz; Imre Romics
Journal:  Pathol Oncol Res       Date:  2006-06-24       Impact factor: 3.201

Review 2.  Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-beta signaling.

Authors:  Shaheen Ahmed; Ali Nawshad
Journal:  Cells Tissues Organs       Date:  2007       Impact factor: 2.481

3.  The transcriptional repressor SNAIL is overexpressed in human colon cancer.

Authors:  Hemant K Roy; Thomas C Smyrk; Jennifer Koetsier; Thomas A Victor; Ramesh K Wali
Journal:  Dig Dis Sci       Date:  2005-01       Impact factor: 3.199

4.  Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.

Authors:  Shouqin Shan; Guangyan Hui; Fanggao Hou; Hua Shi; Guoqing Zhou; Han Yan; Lu Wang; Jinfeng Liu
Journal:  Neurol Sci       Date:  2015-05-23       Impact factor: 3.307

5.  Stable inhibition of specific estrogen receptor α (ERα) phosphorylation confers increased growth, migration/invasion, and disruption of estradiol signaling in MCF-7 breast cancer cells.

Authors:  B P Huderson; T T Duplessis; C C Williams; H C Seger; C G Marsden; K J Pouey; S M Hill; B G Rowan
Journal:  Endocrinology       Date:  2012-06-25       Impact factor: 4.736

6.  ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.

Authors:  Paul Mak; Irwin Leav; Bryan Pursell; Donggoo Bae; Xiaofang Yang; Cherie A Taglienti; Lindsey M Gouvin; Vishva M Sharma; Arthur M Mercurio
Journal:  Cancer Cell       Date:  2010-04-13       Impact factor: 31.743

Review 7.  Histone Deacetylases as New Therapeutic Targets in Triple-negative Breast Cancer: Progress and Promises.

Authors:  Nikolaos Garmpis; Christos Damaskos; Anna Garmpi; Emmanouil Kalampokas; Theodoros Kalampokas; Eleftherios Spartalis; Afrodite Daskalopoulou; Serena Valsami; Michael Kontos; Afroditi Nonni; Konstantinos Kontzoglou; Despina Perrea; Nikolaos Nikiteas; Dimitrios Dimitroulis
Journal:  Cancer Genomics Proteomics       Date:  2017 Sep-Oct       Impact factor: 4.069

8.  Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer.

Authors:  K Lundgren; B Nordenskjöld; G Landberg
Journal:  Br J Cancer       Date:  2009-10-20       Impact factor: 7.640

9.  Expression of e-cadherin in high-risk breast cancer.

Authors:  Eugene M Howard; Stephen K Lau; Robert H Lyles; George G Birdsong; Jay N Umbreit; Ruby Kochhar
Journal:  J Cancer Res Clin Oncol       Date:  2004-10-01       Impact factor: 4.553

10.  The emerging role of CCN6 in breast cancer invasion.

Authors:  Guadalupe Lorenzatti; Wei Huang; Celina G Kleer
Journal:  Cellscience       Date:  2009-10
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