Effect of amino acid surfactants on phase transition of poly(N-isopropylacrylamide) gel.

The volume phase transition behavior of a poly(N-isopropylacrylamide) gel (NIPA gel) in solutions of N-acyl amino acid surfactants were studied as a function of surfactant concentration. The addition of a surfactant beyond the critical micelle concentration (cmc) produced elevation in the transition temperature of the NIPA gel and its swelling. The changes in the volume phase transition temperature and in the swelling of the NIPA gel became more significant with the decreasing size of the amino acid side chain. This result could almost be explained only by the binding amount of surfactant onto the NIPA gel regardless of molecular structure of the amino acid. The binding amount increased in the order of sodium N-lauroyl-glycinate>-alaninate>-valinate>-leucinate>or=-phenylalaninate. For an N-acyl amino acid surfactant to bind onto the NIPA gel, to increase the transition temperature, and to facilitate swelling of the gel, the steric hindrance of the amino acid side chain was more effective than its hydrophobicity.