Literature DB >> 12724232

Epigenetic changes: potential therapeutic targets.

Thea Kalebic1.   

Abstract

Recent advances in human genome research have resulted in novel approaches for the identification of epigenetic modifications associated with cancer. Modulators of DNA methylation and chromatin structure have a dramatic effect on gene expression, cellular proliferation, differentiation, and apoptosis. Molecular pathways regulating epigenetic events that occur during tumorigenesis have been exploited as new targets for therapeutic intervention. Clinical studies exploring the effectiveness of therapeutic agents targeting DNA methylation and acetylation of histones have yielded promising results. Molecular profiles of epigenetic alterations in cancer cells could allow better stratification of patients who may show responsiveness to specific treatments.

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Year:  2003        PMID： 12724232     DOI： 10.1111/j.1749-6632.2003.tb05982.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  7 in total

1.  Expression of cell growth negative regulators MEG3 and GADD45γ is lost in most sporadic human pituitary adenomas.

Authors:  Lisiane Cervieri Mezzomo; Paulo Henrique Gonzales; Frederico Giacomoni Pesce; Nélson Kretzmann Filho; Nelson Pires Ferreira; Miriam Costa Oliveira; Maria Beatriz Fonte Kohek
Journal:  Pituitary       Date:  2012-09       Impact factor: 4.107

2.  Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states.

Authors:  Amelia K Linnemann; Stephen A Krawetz
Journal:  Gene Ther Mol Biol       Date:  2009

3.  Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma.

Authors:  Hiaki Sato; Takashi Oka; Yoko Shinnou; Takami Kondo; Kana Washio; Masayuki Takano; Katsuyoshi Takata; Toshiaki Morito; Xingang Huang; Maiko Tamura; Yuta Kitamura; Nobuya Ohara; Mamoru Ouchida; Koichi Ohshima; Kenji Shimizu; Mitsune Tanimoto; Kiyoshi Takahashi; Masao Matsuoka; Atae Utsunomiya; Tadashi Yoshino
Journal:  Am J Pathol       Date:  2009-12-17       Impact factor: 4.307

4.  Hypermethylation of p15 gene associated with an inferior poor long-term outcome in childhood acute lymphoblastic leukemia.

Authors:  Huirong Mai; Xiaolan Liu; Yixin Chen; Changgang Li; Lizhi Cao; Xiaowen Chen; Senmin Chen; Guosheng Liu; Feiqiu Wen
Journal:  J Cancer Res Clin Oncol       Date:  2016-02       Impact factor: 4.553

5.  Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR.

Authors:  Claudia Gebhard; Lucia Schwarzfischer; Thu Hang Pham; Reinhard Andreesen; Andreas Mackensen; Michael Rehli
Journal:  Nucleic Acids Res       Date:  2006-07-05       Impact factor: 16.971

6.  EpiDBase: a manually curated database for small molecule modulators of epigenetic landscape.

Authors:  Saurabh Loharch; Isha Bhutani; Kamal Jain; Pawan Gupta; Debendra K Sahoo; Raman Parkesh
Journal:  Database (Oxford)       Date:  2015-03-16       Impact factor: 3.451

7.  Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia.

Authors:  Takashi Oka; Hiaki Sato; Mamoru Ouchida; Atae Utsunomiya; Tadashi Yoshino
Journal:  Cancers (Basel)       Date:  2011-02-04       Impact factor: 6.639
  7 in total

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