Literature DB >> 12722822

Brachytherapy dosimetry of 125I and 103Pd sources using an updated cross section library for the MCNP Monte Carlo transport code.

Tim D Bohm1, Paul M DeLuca, Larry A DeWerd.   

Abstract

Permanent implantation of low energy (20-40 keV) photon emitting radioactive seeds to treat prostate cancer is an important treatment option for patients. In order to produce accurate implant brachytherapy treatment plans, the dosimetry of a single source must be well characterized. Monte Carlo based transport calculations can be used for source characterization, but must have up to date cross section libraries to produce accurate dosimetry results. This work benchmarks the MCNP code and its photon cross section library for low energy photon brachytherapy applications. In particular, we calculate the emitted photon spectrum, air kerma, depth dose in water, and radial dose function for both 125I and 103Pd based seeds and compare to other published results. Our results show that MCNP's cross section library differs from recent data primarily in the photoelectric cross section for low energies and low atomic number materials. In water, differences as large as 10% in the photoelectric cross section and 6% in the total cross section occur at 125I and 103Pd photon energies. This leads to differences in the dose rate constant of 3% and 5%, and differences as large as 18% and 20% in the radial dose function for the 125I and 103Pd based seeds, respectively. Using a partially updated photon library, calculations of the dose rate constant and radial dose function agree with other published results. Further, the use of the updated photon library allows us to verify air kerma and depth dose in water calculations performed using MCNP's perturbation feature to simulate updated cross sections. We conclude that in order to most effectively use MCNP for low energy photon brachytherapy applications, we must update its cross section library. Following this update, the MCNP code system will be a very effective tool for low energy photon brachytherapy dosimetry applications.

Entities:  

Mesh:

Substances:

Year:  2003        PMID: 12722822     DOI: 10.1118/1.1562942

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  6 in total

1.  Dosimetric characterization of the GammaClip™ 169Yb low dose rate permanent implant brachytherapy source for the treatment of nonsmall cell lung cancer postwedge resection.

Authors:  Blake Currier; John J Munro; David C Medich
Journal:  Med Phys       Date:  2013-08       Impact factor: 4.071

2.  A novel ytterbium-169 brachytherapy source and delivery system for use in conjunction with minimally invasive wedge resection of early-stage lung cancer.

Authors:  Kara Lynne Leonard; Thomas A DiPetrillo; John J Munro; David E Wazer
Journal:  Brachytherapy       Date:  2010-08-12       Impact factor: 2.362

3.  An EGSnrc investigation of the air-kerma strength, dose rate constant, and radial dose function of 125I brachytherapy sources.

Authors:  Sridhar Sahoo; T Palani Selvam
Journal:  Radiol Phys Technol       Date:  2009-07-11

Review 4.  Monte Carlo methods for device simulations in radiation therapy.

Authors:  Hyojun Park; Harald Paganetti; Jan Schuemann; Xun Jia; Chul Hee Min
Journal:  Phys Med Biol       Date:  2021-09-14       Impact factor: 4.174

5.  Establishment of air kerma reference standard for low dose rate Cs-137 brachytherapy sources.

Authors:  Sunil Dutt Sharma; Sudhir Kumar; P Srinivasan; G Chourasiya
Journal:  J Appl Clin Med Phys       Date:  2011-11-15       Impact factor: 2.102

6.  Dosimetric Characterization of an Intensity-modulated X-Ray Brachytherapy System.

Authors:  Sung-Woo Lee; Evgeny Sozontov; Emil Strumban; Fang-Fang Yin
Journal:  J Med Phys       Date:  2018 Oct-Dec
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.