Literature DB >> 12722155

Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.

Samiulla D Syed1, Mundkinajeddu Deepak, Shivanna Yogisha, Arun P Chandrashekar, Keerthi A Muddarachappa, Prashanth D'Souza, Amit Agarwal, B V Venkataraman.   

Abstract

Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively. Copyright 2003 John Wiley & Sons, Ltd.

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Year:  2003        PMID： 12722155     DOI： 10.1002/ptr.1153

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  8 in total

1.  Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae).

Authors:  Marimuthu Govindarajan; Rajamohan Sivakumar
Journal:  Parasitol Res       Date:  2011-10-20       Impact factor: 2.289

2.  Wedelolactone, an Anti-inflammatory Botanical, Interrupts c-Myc Oncogenic Signaling and Synergizes with Enzalutamide to Induce Apoptosis in Prostate Cancer Cells.

Authors:  Sivalokanathan Sarveswaran; Ritisha Ghosh; Rujul Parikh; Jagadananda Ghosh
Journal:  Mol Cancer Ther       Date:  2016-07-29       Impact factor: 6.261

3.  Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB pathway in RAW 264.7 cells.

Authors:  Fang Yuan; Jie Chen; Ping-ping Sun; Su Guan; Jing Xu
Journal:  J Biomed Sci       Date:  2013-10-31       Impact factor: 8.410

4.  Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway.

Authors:  Yan-Qiu Liu; Zhi-Lai Hong; Li-Bin Zhan; Hui-Ying Chu; Xiao-Zhe Zhang; Guo-Hui Li
Journal:  Sci Rep       Date:  2016-08-25       Impact factor: 4.379

5.  Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway.

Authors:  Yan-Qiu Liu; Xiao-Fei Han; Jun-Xia Bo; Hui-Peng Ma
Journal:  Front Pharmacol       Date:  2016-10-18       Impact factor: 5.810

6.  Wedelolactone Enhances Osteoblastogenesis through ERK- and JNK-mediated BMP2 Expression and Smad/1/5/8 Phosphorylation.

Authors:  Di Zhu; Xue Deng; Xiao-Fei Han; Xiao-Xin Sun; Tao-Wen Pan; Lu-Ping Zheng; Yan-Qiu Liu
Journal:  Molecules       Date:  2018-03-02       Impact factor: 4.411

7.  Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots.

Authors:  Geveraldo Maciel; Adriana Aparecida Lopes; Charles L Cantrell; Suzelei de Castro França; Bianca Waleria Bertoni; Miriam Verginia Lourenço
Journal:  Plant Cell Tissue Organ Cult       Date:  2021-11-22       Impact factor: 2.726

8.  Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt.

Authors:  Sivalokanathan Sarveswaran; Subhash C Gautam; Jagadananda Ghosh
Journal:  Int J Oncol       Date:  2012-10-16       Impact factor: 5.650
  8 in total

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