Literature DB >> 12720510

Fatal fulminant hepatic failure induced by a natural therapy containing kava.

Paul J Gow1, Nathan J Connelly, Richard L Hill, Peter Crowley, Peter W Angus.   

Abstract

We describe a case of acute liver failure and death associated with the use of a preparation containing the "natural" anxiolytic kava (Piper methysticum) and passionflower (Passiflora incarnata). The patient died after a report by the Therapeutic Goods Administration (TGA) warning of the potential for hepatotoxicity associated with the use of kava-containing products. The general public and alternative medicine practitioners need to be aware of the potential for non-prescription drugs to cause serious hepatic reactions.

Entities:  

Mesh:

Substances:

Year:  2003        PMID: 12720510     DOI: 10.5694/j.1326-5377.2003.tb05286.x

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  9 in total

1.  Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis.

Authors:  Akiko Hisamochi; Masayoshi Kage; Teruko Arinaga; Tatsuya Ide; Ichiro Miyajima; Kei Ogata; Reiichiro Kuwahara; Yuriko Koga; Ryukichi Kumashiro; Michio Sata
Journal:  Clin J Gastroenterol       Date:  2013-02-05

2.  Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited.

Authors:  Rolf Teschke; Jerome Sarris; Isaac Schweitzer
Journal:  Br J Clin Pharmacol       Date:  2012-02       Impact factor: 4.335

3.  Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava.

Authors:  Mamta Behl; Abraham Nyska; Rajendra S Chhabra; Gregory S Travlos; Laurene M Fomby; Barney R Sparrow; Milton R Hejtmancik; Po C Chan
Journal:  Food Chem Toxicol       Date:  2011-08-18       Impact factor: 6.023

4.  Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents.

Authors:  Jun Wang; Weiyue Qu; Harry C Bittenbender; Qing X Li
Journal:  J Food Sci Technol       Date:  2013-06-25       Impact factor: 2.701

5.  Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.

Authors:  Ping Zhou; Shimon Gross; Ji-Hua Liu; Bo-Yang Yu; Ling-Ling Feng; Jan Nolta; Vijay Sharma; David Piwnica-Worms; Samuel X Qiu
Journal:  FASEB J       Date:  2010-08-09       Impact factor: 5.191

Review 6.  Toxicity of kava kava.

Authors:  Peter P Fu; Qingsu Xia; Lei Guo; Hongtao Yu; Po-Chuen Chan
Journal:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev       Date:  2008 Jan-Mar       Impact factor: 3.781

Review 7.  Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps.

Authors:  Rolf Teschke; Axel Eickhoff
Journal:  Front Pharmacol       Date:  2015-04-23       Impact factor: 5.810

Review 8.  Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.

Authors:  Flaminia Pantano; Roberta Tittarelli; Giulio Mannocchi; Simona Zaami; Serafino Ricci; Raffaele Giorgetti; Daniela Terranova; Francesco P Busardò; Enrico Marinelli
Journal:  Int J Mol Sci       Date:  2016-04-16       Impact factor: 5.923

Review 9.  Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation.

Authors:  Christian Frenzel; Rolf Teschke
Journal:  Int J Mol Sci       Date:  2016-04-27       Impact factor: 5.923

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.