| Literature DB >> 12719941 |
Wafaa M Bassuny1, Kenji Ihara2, Junko Kimura2, Shigeki Ichikawa2, Ryuichi Kuromaru2, Kenichi Miyako2, Kouichi Kusuhara2, Yuka Sasaki2, Hitoshi Kohno3, Nobuo Matsuura4, Sankei Nishima5, Toshiro Hara2.
Abstract
Interleukin-12 (IL-12) secreted from macrophages or dendritic cells plays an important role in the protection against intracellular pathogens as well as the developmental commitment of T helper 1 cells. IL-12 exerts its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rbeta1 and IL 12Rbeta2. In this paper, we performed association studies between the three reported polymorphisms (Q214R, M365T and G378R) of the IL-12Rbeta1 gene or the newly identified polymorphisms (P238L, IVS9 -7G>A, IVS13 -121G>A, A643T, P779P and c.3283T>G) of the IL-12Rbeta2 gene, and the development of type 1 diabetes or atopic asthma as representative Th1- and Th2- dominant diseases, respectively. The association study of each polymorphism of the IL-12Rbeta1 or IL-12Rbeta2 gene and type 1 diabetes or asthma showed that these IL-12R genes did not contribute to the development of type 1 diabetes or asthma in the Japanese population. Further analysis in individuals with susceptibility to intracellular pathogens may elucidate the importance of the IL-12R genes.Entities:
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Year: 2003 PMID： 12719941 DOI： 10.1007/s00251-003-0568-7
Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846