OBJECTIVE: Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were therefore targeted in the present study. METHODS: A comprehensive series of neuropsychological tests examining attention, memory and executive functions was performed in a group of 14 TS/OCD in co-occurrence with OCD patients and a matched control group. RESULTS: While attentional and memory mechanisms were not altered, TS/OCS patients showed deficits in executive functions predominantly in the areas of response inhibition and action monitoring. CONCLUSIONS: These findings provide further evidence for a substantial impairment of the frontal-striatal-thalamic-frontal circuit. We propose that the deficits in monitoring, error detection and response inhibition constitute the major impairment of TS/OCD patients in the cognitive domain.
OBJECTIVE: Fronto-striatal dysfunction has been discussed as underlying symptoms of Tourette syndrome (TS) with co-morbid Obsessive Compulsive Disorder (OCD). This suggests possible impairments of executive functions in this disorder, which were therefore targeted in the present study. METHODS: A comprehensive series of neuropsychological tests examining attention, memory and executive functions was performed in a group of 14 TS/OCD in co-occurrence with OCDpatients and a matched control group. RESULTS: While attentional and memory mechanisms were not altered, TS/OCS patients showed deficits in executive functions predominantly in the areas of response inhibition and action monitoring. CONCLUSIONS: These findings provide further evidence for a substantial impairment of the frontal-striatal-thalamic-frontal circuit. We propose that the deficits in monitoring, error detection and response inhibition constitute the major impairment of TS/OCDpatients in the cognitive domain.
Authors: Denis G Sukhodolsky; Angeli Landeros-Weisenberger; Lawrence Scahill; James F Leckman; Robert T Schultz Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-11 Impact factor: 8.829
Authors: Cameron B Jeter; Saumil S Patel; Jeffrey S Morris; Alice Z Chuang; Ian J Butler; Anne B Sereno Journal: J Child Psychol Psychiatry Date: 2014-07-16 Impact factor: 8.982
Authors: A E Ortiz; A Morer; E Moreno; M T Plana; C Cordovilla; L Lázaro Journal: Eur Arch Psychiatry Clin Neurosci Date: 2015-09-15 Impact factor: 5.270