Literature DB >> 12719519

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.

Davor Pavlović1, David C A Neville, Olivier Argaud, Baruch Blumberg, Raymond A Dwek, Wolfgang B Fischer, Nicole Zitzmann.   

Abstract

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12719519      PMCID： PMC156333          DOI： 10.1073/pnas.1031527100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

1.  Single-channel currents recorded from membrane of denervated frog muscle fibres.

Authors:  E Neher; B Sakmann
Journal:  Nature       Date:  1976-04-29       Impact factor: 49.962

2.  Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1.

Authors:  Che Ma; Francesca M Marassi; David H Jones; Suzana K Straus; Stephan Bour; Klaus Strebel; Ulrich Schubert; Myrta Oblatt-Montal; Mauricio Montal; Stanley J Opella
Journal:  Protein Sci       Date:  2002-03       Impact factor: 6.725

3.  Subcellular localization and topology of the p7 polypeptide of hepatitis C virus.

Authors:  Séverine Carrère-Kremer; Claire Montpellier-Pala; Laurence Cocquerel; Czeslaw Wychowski; François Penin; Jean Dubuisson
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

4.  Alphavirus 6K proteins form ion channels.

Authors:  Julian V Melton; Gary D Ewart; Ronald C Weir; Philip G Board; Eva Lee; Peter W Gage
Journal:  J Biol Chem       Date:  2002-09-12       Impact factor: 5.157

5.  Antiviral effects of an iminosugar derivative on flavivirus infections.

Authors:  Shu-Fen Wu; Chyan-Jang Lee; Ching-Len Liao; Raymond A Dwek; Nicole Zitzmann; Yi-Ling Lin
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

6.  Amantadine blocks channel activity of the transmembrane segment of the NB protein from influenza B.

Authors:  W B Fischer; M Pitkeathly; M S Sansom
Journal:  Eur Biophys J       Date:  2001-10       Impact factor: 1.733

7.  Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties.

Authors:  M Montal; P Mueller
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

8.  Bundles consisting of extended transmembrane segments of Vpu from HIV-1: computer simulations and conductance measurements.

Authors:  F S Cordes; A D Tustian; M S P Sansom; A Watts; W B Fischer
Journal:  Biochemistry       Date:  2002-06-11       Impact factor: 3.162

9.  The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.

Authors:  Stephen D C Griffin; Lucy P Beales; Dean S Clarke; Oliver Worsfold; Stephen D Evans; Joachim Jaeger; Mark P G Harris; David J Rowlands
Journal:  FEBS Lett       Date:  2003-01-30       Impact factor: 4.124

10.  The molecular basis of the specific anti-influenza action of amantadine.

Authors:  A J Hay; A J Wolstenholme; J J Skehel; M H Smith
Journal:  EMBO J       Date:  1985-11       Impact factor: 11.598
View more
  144 in total

1.  NMR structure and ion channel activity of the p7 protein from hepatitis C virus.

Authors:  Roland Montserret; Nathalie Saint; Christophe Vanbelle; Andrés Gerardo Salvay; Jean-Pierre Simorre; Christine Ebel; Nicolas Sapay; Jean-Guillaume Renisio; Anja Böckmann; Eike Steinmann; Thomas Pietschmann; Jean Dubuisson; Christophe Chipot; François Penin
Journal:  J Biol Chem       Date:  2010-07-28       Impact factor: 5.157

Review 2.  Ion channels as antivirus targets.

Authors:  Xin Liang; Zhi-Yuan Li
Journal:  Virol Sin       Date:  2010-07-28       Impact factor: 4.327

3.  Secondary structure, dynamics, and architecture of the p7 membrane protein from hepatitis C virus by NMR spectroscopy.

Authors:  Gabriel A Cook; Stanley J Opella
Journal:  Biochim Biophys Acta       Date:  2010-08-18

Review 4.  Comparative NMR studies demonstrate profound differences between two viroporins: p7 of HCV and Vpu of HIV-1.

Authors:  Gabriel A Cook; Hua Zhang; Sang Ho Park; Yan Wang; Stanley J Opella
Journal:  Biochim Biophys Acta       Date:  2010-08-18

5.  Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing.

Authors:  Jyoti Dev; Sven Brüschweiler; Bo Ouyang; James J Chou
Journal:  J Biomol NMR       Date:  2015-02-28       Impact factor: 2.835

Review 6.  The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.

Authors:  D M D'Agostino; M Silic-Benussi; H Hiraragi; M D Lairmore; V Ciminale
Journal:  Cell Death Differ       Date:  2005-08       Impact factor: 15.828

Review 7.  Studying hepatitis C virus: making the best of a bad virus.

Authors:  Timothy L Tellinghuisen; Matthew J Evans; Thomas von Hahn; Shihyun You; Charles M Rice
Journal:  J Virol       Date:  2007-05-23       Impact factor: 5.103

8.  Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus.

Authors:  MinKyung Yi; Yinghong Ma; Jeremy Yates; Stanley M Lemon
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

9.  The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus.

Authors:  Wen Chen; Jyoti Dev; Julija Mezhyrova; Liqiang Pan; Alessandro Piai; James J Chou
Journal:  Structure       Date:  2018-03-15       Impact factor: 5.006

Review 10.  Sequence diversity of hepatitis C virus: implications for immune control and therapy.

Authors:  Joerg Timm; Michael Roggendorf
Journal:  World J Gastroenterol       Date:  2007-09-28       Impact factor: 5.742
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.