Literature DB >> 12717

Comparative in vitro studies of cinoxacin, nalidixic acid, and oxolinic acid.

R C Gordon, L I Stevens, C E Edmiston, K Mohan.   

Abstract

Cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138 Shigella isolates and somewhat less active than oxolinic acid on a weight basis. Cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in Mueller-Hinton agar. Plate dilution studies of the effect of changes in agar pH on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing pH. Protein binding investigations revealed a high degree of binding, with nalidixic acid > oxolinic acid > cinoxacin.

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Year:  1976        PMID： 12717      PMCID： PMC429866          DOI： 10.1128/AAC.10.6.918

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Antimicrobial resistance of Shigellae isolated in Michigan.

Authors:  R C Gordon; T R Thompson; W Carlson; J W Dyke; L I Stevens
Journal:  JAMA       Date:  1975-03-17       Impact factor: 56.272

2.  In vitro activity of cinoxacin, an organic acid antibacterial.

Authors:  S Kurtz; M Turck
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

3.  Serum protein binding of erythromycin, lincomycin, and clindamycin.

Authors:  R C Gordon; C Regamey; W M Kirby
Journal:  J Pharm Sci       Date:  1973-07       Impact factor: 3.534

4.  Compound 64716, a new synthetic antibacterial agent.

Authors:  W E Wick; D A Preston; W A White; R S Gordee
Journal:  Antimicrob Agents Chemother       Date:  1973-10       Impact factor: 5.191

5.  Nalidixic acid and oxolinic acid in the treatment of chronic bacteriuria.

Authors:  E Atlas; H Clark; F Silverblatt; M Turck
Journal:  Ann Intern Med       Date:  1969-04       Impact factor: 25.391

6.  Cinoxacin: in vitro antibacterial studies of a new synthetic organic acid.

Authors:  R M Lumish; C W Norden
Journal:  Antimicrob Agents Chemother       Date:  1975-02       Impact factor: 5.191

7.  Antibacterial activity of cinoxacin in vitro.

Authors:  H Giamarellou; G G Jackson
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

8.  Antimicrobial susceptibilities of shigellae isolated in Houston, Texas, in 1974.

Authors:  P A Byers; H L Dupont; M C Goldschmidt
Journal:  Antimicrob Agents Chemother       Date:  1976-02       Impact factor: 5.191

9.  Microbioassay of antimicrobial agents.

Authors:  H J Simon; E J Yin
Journal:  Appl Microbiol       Date:  1970-04
  9 in total
  1 in total

Review 1.  Cinoxacin. A review of its pharmacological properties and therapeutic efficacy in the treatment of urinary tract infections.

Authors:  T S Sisca; R C Heel; J A Romankiewicz
Journal:  Drugs       Date:  1983-06       Impact factor: 9.546
  1 in total

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