S M Ng1, Y Kumar, D Cody, C S Smith, M Didi. 1. Endocrinology Department, Royal Liverpool Chidren's Hospital, Liverpool, UK. ngszemay@yahoo.com
Abstract
AIMS: (1) To assess the value of cranial magnetic resonance imaging (MRI) scans in the investigation of girls with central precocious puberty (CPP); and (2) to determine the clinical predictors of abnormal cranial MRI scans in these patients. METHODS: A retrospective study of 67 girls diagnosed with CPP who underwent cranial MRI scans at diagnosis. Patients with neurological signs or symptoms at presentation were excluded. RESULTS: The mean age of onset of puberty was 6.2 years (range 2.0-7.9). Intracranial abnormalities were present in 10 (15%) patients (MR+), while 57 (85%) had no abnormalities (MR-). There was no statistical difference between MR+ patients and MR- patients at presentation with respect to age of onset of puberty, pubertal stage, bone age advance, pelvic ultrasound findings, or height or body mass index standard deviation scores (SDS). CONCLUSION: Girls with CPP should have a cranial MRI scan as part of their assessment since clinical features, including age, are not helpful in predicting those with underlying pathology. Implementation of such an approach may have a substantial effect on clinical practice and healthcare cost.
AIMS: (1) To assess the value of cranial magnetic resonance imaging (MRI) scans in the investigation of girls with central precocious puberty (CPP); and (2) to determine the clinical predictors of abnormal cranial MRI scans in these patients. METHODS: A retrospective study of 67 girls diagnosed with CPP who underwent cranial MRI scans at diagnosis. Patients with neurological signs or symptoms at presentation were excluded. RESULTS: The mean age of onset of puberty was 6.2 years (range 2.0-7.9). Intracranial abnormalities were present in 10 (15%) patients (MR+), while 57 (85%) had no abnormalities (MR-). There was no statistical difference between MR+ patients and MR- patients at presentation with respect to age of onset of puberty, pubertal stage, bone age advance, pelvic ultrasound findings, or height or body mass index standard deviation scores (SDS). CONCLUSION:Girls with CPP should have a cranial MRI scan as part of their assessment since clinical features, including age, are not helpful in predicting those with underlying pathology. Implementation of such an approach may have a substantial effect on clinical practice and healthcare cost.
Authors: H Jung; P Carmel; M S Schwartz; J W Witkin; K H Bentele; M Westphal; J H Piatt; M E Costa; A Cornea; Y J Ma; S R Ojeda Journal: J Clin Endocrinol Metab Date: 1999-12 Impact factor: 5.958
Authors: E Cacciari; E Fréjaville; A Cicognani; P Pirazzoli; G Frank; A Balsamo; D Tassinari; F Zappulla; R Bergamaschi; G F Cristi Journal: J Pediatr Date: 1983-03 Impact factor: 4.406
Authors: M J Mansfield; D E Beardsworth; J S Loughlin; J D Crawford; H H Bode; J Rivier; W Vale; D C Kushner; J F Crigler; W F Crowley Journal: N Engl J Med Date: 1983-11-24 Impact factor: 91.245
Authors: Signe Sloth Mogensen; Lise Aksglaede; Annette Mouritsen; Kaspar Sørensen; Katharina M Main; Peter Gideon; Anders Juul Journal: PLoS One Date: 2012-01-12 Impact factor: 3.240