BACKGROUND: The objective of this study was to evaluate the predictive value of interleukin-6 (IL-6) in cervical secretions for preterm delivery before 34+0 gestational weeks in patients with preterm labor. METHODS: In this prospective study, 31 patients were enrolled with preterm labor and intact membranes. Cervical swabs were taken on admission and the concentration of IL-6 was measured. The gestational age at the time of admission and delivery, as well as the time interval to delivery, were evaluated and compared with the concentration of IL-6 on admission. RESULTS: Cervical IL-6 was significantly elevated in the preterm delivery group (< 34+0 gestational weeks, p < 0.05). Choosing 20 pg/ml as a cut-off concentration, cervical IL-6 had a sensitivity and negative predictive value of 100%, a specificity of 67% and a positive predictive value of 47%. Concerning the time interval to delivery, the sensitivity of IL-6 was 100% and the specificity 57% for delivery within 2 days and 100% and 64% for delivery within 7 days. CONCLUSIONS: Cervical IL-6 is a new, promising diagnostic tool to identify patients at high risk of preterm delivery.
BACKGROUND: The objective of this study was to evaluate the predictive value of interleukin-6 (IL-6) in cervical secretions for preterm delivery before 34+0 gestational weeks in patients with preterm labor. METHODS: In this prospective study, 31 patients were enrolled with preterm labor and intact membranes. Cervical swabs were taken on admission and the concentration of IL-6 was measured. The gestational age at the time of admission and delivery, as well as the time interval to delivery, were evaluated and compared with the concentration of IL-6 on admission. RESULTS: Cervical IL-6 was significantly elevated in the preterm delivery group (< 34+0 gestational weeks, p < 0.05). Choosing 20 pg/ml as a cut-off concentration, cervical IL-6 had a sensitivity and negative predictive value of 100%, a specificity of 67% and a positive predictive value of 47%. Concerning the time interval to delivery, the sensitivity of IL-6 was 100% and the specificity 57% for delivery within 2 days and 100% and 64% for delivery within 7 days. CONCLUSIONS: Cervical IL-6 is a new, promising diagnostic tool to identify patients at high risk of preterm delivery.
Authors: Steve N Caritis; Gary Hankins; Mary Hebert; David M Haas; Mahmoud Ahmed; Hyagriv Simhan; Laura A Haneline; John Harris; Justine Chang; Alyssa Stephenson Famy; Patrick Yorio; Zhaoxia Ren; Mary E D'Alton; Raman Venkataramanan Journal: Am J Perinatol Date: 2017-11-15 Impact factor: 1.862
Authors: Bryan S Michalowicz; M John Novak; James S Hodges; Anthony DiAngelis; William Buchanan; Panos N Papapanou; Dennis A Mitchell; James E Ferguson; Virginia Lupo; James Bofill; Stephen Matseoane; Michelle Steffen; Jeffrey L Ebersole Journal: J Periodontol Date: 2009-11 Impact factor: 6.993