Literature DB >> 1271532

Isolation and preliminary characterization of temperature-sensitive mutants of Newcastle disease virus.

J E Tsipis, M A Bratt.   

Abstract

Temperature-sensitive (ts) mutants of Newcastle disease virus have been isolated and characterized genetically (complementation), biochemically (RNA synthesis) and biologically (fusion from within and hemadsorption). Fifteen of these mutants have been divided into five complementation groups. Groups A (five mutants) and E (one mutant) are ts for RNA synthesis (RNA-) as well as for the other functions. Group B contains four RNA+ mutants of which one is ts for fusion, one for hemadsorption and two for neither function. Group C contains one RNA+ mutant which is a poor cell fuser. Group D contains two RNA+ mutants which are ts for fusion. In addition, two noncomplementing mutants (group BC) fail to complement both group B and group C mutants while exhibiting complementation with mutants in groups A, D, and E.

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Year:  1976        PMID： 1271532      PMCID： PMC354783          DOI： 10.1128/JVI.18.3.848-855.1976

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  A temperature-sensitive mutant of Sendai virus with an altered hemagglutinin-neuraminidase polypeptide: consequences for virus assembly and cytopathology.

Authors:  A Portner; R A Scroggs; P S Marx; D W Kingsbury
Journal:  Virology       Date:  1975-09       Impact factor: 3.616

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Isolation and characterization of Sendai virus temperature-sensitive mutants.

Authors:  A Portner; P A Marx; D W Kingsbury
Journal:  J Virol       Date:  1974-02       Impact factor: 5.103

4.  The homologies of spontaneous and induced temperature-sensitive mutants of vesicular stomatitis virus isolated in chick embryo and BHK 21 cells.

Authors:  A Flamand; C R Pringle
Journal:  J Gen Virol       Date:  1971-05       Impact factor: 3.891

5.  Isolation and characterization of temperature-sensitive mutants of vesicular stomatitis virus.

Authors:  A F Holloway; P K Wong; D V Cormack
Journal:  Virology       Date:  1970-12       Impact factor: 3.616

6.  Conditional dependence of fusion from within and other cell membrane alterations by Newcastle disease virus.

Authors:  W R Gallaher; M A Bratt
Journal:  J Virol       Date:  1974-10       Impact factor: 5.103

7.  Isolation and characterization of conditional-lethal mutants of Sindbis virus.

Authors:  B W Burge; E R Pfefferkorn
Journal:  Virology       Date:  1966-10       Impact factor: 3.616

8.  Protein synthesis in Newcastle disease virus-infected chicken embryo cells.

Authors:  L E Hightower; M A Bratt
Journal:  J Virol       Date:  1974-04       Impact factor: 5.103

9.  [Study of thermosensitive mutants of vesicular stomatitis virus (VSV). Classification of some mutants on a functional basis].

Authors:  F Lafay
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1969-05-12

10.  Hemolytic interaction of Newcastle disease virus and chicken erythrocytes. II. Determining factors.

Authors:  L A Clavell; M A Bratt
Journal:  Appl Microbiol       Date:  1972-03
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  14 in total

1.  Intracellular processing of the paramyxovirus F protein: critical role of the predicted amphipathic alpha helix adjacent to the fusion domain.

Authors:  C Wang; G Raghu; T Morrison; M E Peeples
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

2.  Noncytopathic mutants of Newcastle disease virus.

Authors:  C H Madansky; M A Bratt
Journal:  J Virol       Date:  1978-06       Impact factor: 5.103

3.  Complementation analysis of measles virus temperature-sensitive mutants.

Authors:  A M Breschkin; F Rapp; F E Payne
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

4.  Characterization of a live, attenuated human parainfluenza type 3 virus candidate vaccine strain.

Authors:  R Ray; K Meyer; F K Newman; R B Belshe
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

5.  Biological consequences of neuraminidase deficiency in Newcastle disease virus.

Authors:  G W Smith; L E Hightower
Journal:  J Virol       Date:  1983-09       Impact factor: 5.103

6.  Mutation in the matrix protein of Newcastle disease virus can result in decreased fusion glycoprotein incorporation into particles and decreased infectivity.

Authors:  M E Peeples; M A Bratt
Journal:  J Virol       Date:  1984-07       Impact factor: 5.103

7.  Thermostabilities of virion activities of Newcastle disease virus: evidence that the temperature-sensitive mutants in complementation groups B, BC, and C have altered HN proteins.

Authors:  M E Peeples; R L Glickman; M A Bratt
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

8.  RNA synthesis by Newcastle disease virus temperature-sensitive mutants in two RNA-negative complementation groups.

Authors:  M E Peeples; L L Rasenas; M A Bratt
Journal:  J Virol       Date:  1982-06       Impact factor: 5.103

9.  UV irradiation analysis of complementation between, and replication of, RNA-negative temperature-sensitive mutants of Newcastle disease virus.

Authors:  M E Peeples; M A Bratt
Journal:  J Virol       Date:  1982-03       Impact factor: 5.103

10.  Temperature-sensitive phenotype of the human parainfluenza virus type 3 candidate vaccine strain (cp45) correlates with a defect in the L gene.

Authors:  R Ray; M S Galinski; B R Heminway; K Meyer; F K Newman; R B Belshe
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103
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