Literature DB >> 12715069

New evidence of spontaneous cure in human Chagas' disease.

Sonia S Francolino1, Antonio Fernandez Antunes, Rodolfo Talice, Rachel Rosa, Joel Selanikio, Joffre Marcondes de Rezende, Alvaro J Romanha, João Carlos Pinto Dias.   

Abstract

A new case of spontaneous cure of human Chagas' disease is described in Uruguay. An 87-year-old man who had a typical acute phase of Trypanosoma cruzi infection in 1947 and never received specific treatment against the disease, when examined in 1998 revealed several completely negative parasitological and serological tests, including traditional serology, PCR and flow cytometry. As a whole, such findings fulfill the current criteria to define the cure of Chagas' disease. Clinical data suggest the possibility of a benign evolution of Chagas' disease in this case, but the basic findings (slight cardiac and esophageal impairment) could also be due to the advanced age of the patient.

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Year:  2003        PMID: 12715069     DOI: 10.1590/s0037-86822003000100014

Source DB:  PubMed          Journal:  Rev Soc Bras Med Trop        ISSN: 0037-8682            Impact factor:   1.581


  12 in total

Review 1.  Chronic Chagas Disease-the Potential Role of Reinfections in Cardiomyopathy Pathogenesis.

Authors:  Christian Olivo Freites; Hendrik Sy; Amal Gharamti; Nelson I Agudelo Higuita; Carlos Franco-Paredes; José Antonio Suárez; Andrés F Henao-Martínez
Journal:  Curr Heart Fail Rep       Date:  2022-08-11

2.  Antibody levels correlate with detection of Trypanosoma cruzi DNA by sensitive polymerase chain reaction assays in seropositive blood donors and possible resolution of infection over time.

Authors:  Ester C Sabino; Tzong-Hae Lee; Lani Montalvo; Megan L Nguyen; David A Leiby; Danielle M Carrick; Marcia M Otani; Elizabeth Vinelli; David Wright; Susan L Stramer; Michael Busch
Journal:  Transfusion       Date:  2012-09-25       Impact factor: 3.157

3.  Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease.

Authors:  Rodolfo Viotti; Carlos Vigliano; María Gabriela Alvarez; Bruno Lococo; Marcos Petti; Graciela Bertocchi; Alejandro Armenti; Ana María De Rissio; Gretchen Cooley; Rick Tarleton; Susana Laucella
Journal:  PLoS Negl Trop Dis       Date:  2011-09-06

4.  Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection.

Authors:  Juan Bustamante; Rick Tarleton
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-04-28       Impact factor: 2.743

5.  Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial.

Authors:  Anis Rassi; José Antonio Marin; Anis Rassi
Journal:  Mem Inst Oswaldo Cruz       Date:  2017-02-16       Impact factor: 2.743

6.  Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection.

Authors:  Angela D Pack; Matthew H Collins; Charles S Rosenberg; Rick L Tarleton
Journal:  PLoS Pathog       Date:  2018-11-12       Impact factor: 6.823

7.  Risk factors and select cardiac characteristics in dogs naturally infected with Trypanosoma cruzi presenting to a teaching hospital in Texas.

Authors:  Alyssa C Meyers; Sarah A Hamer; Derek Matthews; Sonya G Gordon; Ashley B Saunders
Journal:  J Vet Intern Med       Date:  2019-05-22       Impact factor: 3.333

8.  A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease.

Authors:  André Azevedo Reis Teixeira; Luis Rodriguez Carnero; Andréia Kuramoto; Fenny Hui Fen Tang; Carlos Hernique Gomes; Natalia Bueno Pereira; Léa Campos de Oliveira; Regina Garrini; Jhonatas Sirino Monteiro; João Carlos Setubal; Ester Cerdeira Sabino; Renata Pasqualini; Walter Colli; Wadih Arap; Maria Júlia Manso Alves; Edécio Cunha-Neto; Ricardo José Giordano
Journal:  iScience       Date:  2021-05-15

9.  The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to Trypanosoma cruzi in Serodiscordant Subjects.

Authors:  Melisa D Castro Eiro; María G Alvarez; Gretchen Cooley; Rodolfo J Viotti; Graciela L Bertocchi; Bruno Lococo; María C Albareda; Ana M De Rissio; María A Natale; Cecilia Parodi; Rick L Tarleton; Susana A Laucella
Journal:  Front Immunol       Date:  2017-09-15       Impact factor: 7.561

10.  Nationwide Exposure of U.S. Working Dogs to the Chagas Disease Parasite, Trypanosoma cruzi.

Authors:  Alyssa C Meyers; Julia C Purnell; Megan M Ellis; Lisa D Auckland; Marvin Meinders; Sarah A Hamer
Journal:  Am J Trop Med Hyg       Date:  2020-05       Impact factor: 2.345

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