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Literature DB >> 12714738

Micellar nanocontainers distribute to defined cytoplasmic organelles.

Radoslav Savic¹, Laibin Luo, Adi Eisenberg, Dusica Maysinger.

Abstract

Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver drugs to specified subcellular targets.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12714738 DOI： 10.1126/science.1078192

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

112 in total

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Micellar nanocontainers distribute to defined cytoplasmic organelles.

1. 2,1,3-Benzothiadiazole (BTD)-moiety-containing red emitter conjugated amphiphilic poly(ethylene glycol)-block-poly(epsilon-caprolactone) copolymers for bioimaging.

2. A novel one-step drug-loading procedure for water-soluble amphiphilic nanocarriers.

3. Nanomedicine in the diagnosis and therapy of neurodegenerative disorders.

4. Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs.

5. Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells.

6. Optimization of a nanomedicine-based silicon phthalocyanine 4 photodynamic therapy (Pc 4-PDT) strategy for targeted treatment of EGFR-overexpressing cancers.

7. Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy.

Review 8. Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies.

9. Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging.

10. Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery.