| Literature DB >> 1271405 |
S Fabrissin, M de Nardo, C Nisi, L Morasca, E Dolfini, G Franchi.
Abstract
Several 5-diethylaminomethyl derivatives and nitrogen mustards of uracil and 2-thiouracil have been synthesized and tested for their potential anticancer activity in vitro on KB cells and in vivo on Ehrlich carcinoma. Among the alkylating derivatives tested several showed cytotoxic activity in vitro and compound V [5-[bis(2-chloroethyl) amino] methyl-6-propyluracil hydrochloride] showed both in vitro and in vivo anticancer activity.Entities:
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Year: 1976 PMID： 1271405 DOI： 10.1021/jm00227a012
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446