| Literature DB >> 12713841 |
Rosa M Villar1, José Gil-Longo, Antonio H Daranas, María L Souto, José J Fernández, Solange Peixinho, Miguel A Barral, Gilmar Santafé, Jaime Rodríguez, Carlos Jiménez.
Abstract
Ten zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthus nymphaeus and Zoanthus sp.) along with one semisynthetic derivative were evaluated for their antiplatelet activities on human platelet aggregation induced by several stimulating agents. 11-Hydroxyzoanthamine (11) and a synthetic derivative of norzoanthamine (16) showed strong inhibition against thrombin-, collagen- and arachidonic acid-induced aggregation, zoanthenol (15) displayed a selective inhibitory activity induced by collagen, while zoanthaminone (10) behaved as a potent aggregant agent. These evaluations allowed us to deduce several structure-activity relationships and suggest some mechanisms of action for this type of compounds.Entities:
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Year: 2003 PMID： 12713841 DOI： 10.1016/s0968-0896(03)00107-x
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641